Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-DK-AA75-01A-11R-A39I-07

e9a02f94-08c9-505d-b76d-58306fac88e1

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
11.1695138
os_event
true
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • MYC_TARGETS_V2+0.470
  • E2F_TARGETS+0.240
  • KRAS_SIGNALING_DN+0.230
  • MYC_TARGETS_V1+0.220
  • SPERMATOGENESIS+0.210
  • DNA_REPAIR+0.190
  • OXIDATIVE_PHOSPHORYLATION+0.190
  • PANCREAS_BETA_CELLS+0.100
  • G2M_CHECKPOINT+0.060
  • BILE_ACID_METABOLISM+0.030

Top 10 suppressed

  • TGF_BETA_SIGNALING-0.560
  • INTERFERON_GAMMA_RESPONSE-0.530
  • INFLAMMATORY_RESPONSE-0.520
  • INTERFERON_ALPHA_RESPONSE-0.520
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.510
  • IL6_JAK_STAT3_SIGNALING-0.510
  • PROTEIN_SECRETION-0.480
  • TNFA_SIGNALING_VIA_NFKB-0.480
  • UV_RESPONSE_DN-0.480
  • ALLOGRAFT_REJECTION-0.470

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-P3-A6T6-01A-11R-A34R-07
head-neck@1
0.949
2SRR8526719
lung-landscapes@6
cohortMD10.938
3TCGA-E5-A4U1-01A-11R-A31N-07
bladder-landscape@3
0.935
4TCGA-CN-A63U-01A-11R-A30B-07
head-neck@1
0.931
5TCGA-OL-A5RZ-01A-11R-A28M-07
breast-umap@18
C0.921
6TCGA-77-A5G7-01B-11R-A27Q-07
lung-landscapes@6
cohortSQ10.916
7R16
bladder-landscape@3
0.915
8TCGA-E9-A54Y-01A-11R-A466-07
breast-umap@18
B0.913
9TCGA-AN-A0AR-01A-11R-A00Z-07
breast-umap@18
E0.911
10TCGA-QK-A8Z7-01A-11R-A39I-07
head-neck@1
0.911

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 12 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V20.470Idelalisib— uncovered
E2F_TARGETS0.240Inavolisib— uncovered
KRAS_SIGNALING_DN0.230Remibrutinib— uncovered
MYC_TARGETS_V10.220Inavolisib— uncovered
SPERMATOGENESIS0.210Inavolisib— uncovered
DNA_REPAIR0.190Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.190Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.100Cobimetinib— uncovered
G2M_CHECKPOINT0.060Inavolisib— uncovered
BILE_ACID_METABOLISM0.030Inavolisib— uncovered
FATTY_ACID_METABOLISM0.030Inavolisib— uncovered
PEROXISOME0.010Idelalisib— uncovered