SRR1404601
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- CHOLESTEROL_HOMEOSTASIS+0.326
- BILE_ACID_METABOLISM+0.219
- HEME_METABOLISM+0.174
- TGF_BETA_SIGNALING+0.166
- MITOTIC_SPINDLE+0.133
- PROTEIN_SECRETION+0.115
- XENOBIOTIC_METABOLISM+0.112
- FATTY_ACID_METABOLISM+0.111
- ANDROGEN_RESPONSE+0.110
- PEROXISOME+0.097
Top 10 suppressed
- PANCREAS_BETA_CELLS-0.374
- OXIDATIVE_PHOSPHORYLATION-0.373
- HEDGEHOG_SIGNALING-0.325
- ALLOGRAFT_REJECTION-0.284
- G2M_CHECKPOINT-0.284
- MYC_TARGETS_V2-0.274
- E2F_TARGETS-0.268
- MYC_TARGETS_V1-0.263
- ANGIOGENESIS-0.225
- PI3K_AKT_MTOR_SIGNALING-0.214
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-86-8073-01A-11R-2241-07 | — | cohortA1 | 0.799 |
| 2 | BS_A1VEGWTR | pilocytic astrocytoma | — | 0.740 |
| 3 | SRR1473979 | GTEX | — | 0.712 |
| 4 | BS_55P8HPYD | pilocytic astrocytoma | — | 0.700 |
| 5 | TCGA-E2-A15P-01A-11R-A115-07 | — | B | 0.695 |
| 6 | MNG1049 | — | — | 0.691 |
| 7 | C3L-00893 | — | cohortA1 | 0.691 |
| 8 | TCGA-55-8087-01A-11R-2241-07 | — | cohortA1 | 0.688 |
| 9 | BS_PEP9NZXN | low-grade glioma | — | 0.685 |
| 10 | TCGA-55-1592-01A-01R-0946-07 | — | cohortA1 | 0.683 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 14 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| CHOLESTEROL_HOMEOSTASIS | 0.326 | Remibrutinib | — uncovered |
| BILE_ACID_METABOLISM | 0.219 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.174 | Temsirolimus | — uncovered |
| TGF_BETA_SIGNALING | 0.166 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.133 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.115 | Remibrutinib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.112 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.111 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.110 | Inavolisib | — uncovered |
| PEROXISOME | 0.097 | Idelalisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.020 | Inavolisib | — uncovered |
| IL2_STAT5_SIGNALING | 0.007 | Idelalisib | — uncovered |
| ADIPOGENESIS | 0.006 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.006 | Idelalisib | — uncovered |