SRR1473979
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- CHOLESTEROL_HOMEOSTASIS+0.254
- BILE_ACID_METABOLISM+0.160
- PROTEIN_SECRETION+0.115
- MYOGENESIS+0.105
- FATTY_ACID_METABOLISM+0.054
- SPERMATOGENESIS+0.029
- UV_RESPONSE_DN+0.012
- TGF_BETA_SIGNALING+0.005
- ESTROGEN_RESPONSE_EARLY-0.004
- HEDGEHOG_SIGNALING-0.013
Top 10 suppressed
- E2F_TARGETS-0.453
- G2M_CHECKPOINT-0.425
- MYC_TARGETS_V2-0.414
- MYC_TARGETS_V1-0.409
- IL6_JAK_STAT3_SIGNALING-0.382
- TNFA_SIGNALING_VIA_NFKB-0.373
- INTERFERON_GAMMA_RESPONSE-0.344
- UNFOLDED_PROTEIN_RESPONSE-0.313
- COAGULATION-0.303
- INFLAMMATORY_RESPONSE-0.302
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | C3L-02958 | — | cohortA1 | 0.881 |
| 2 | BS_ME3HKN2C | Ganglioglioma | — | 0.864 |
| 3 | BS_273HKCT4 | DNET | — | 0.862 |
| 4 | SRR1339387 | GTEX | — | 0.854 |
| 5 | MDT-AP-0153 | Med | Medulloblastoma | 0.850 |
| 6 | BS_T2QPMZCM | low-grade glioma | — | 0.850 |
| 7 | TCGA-J2-A4AD-01A-11R-A24H-07 | — | cohortA1 | 0.845 |
| 8 | SRR1358501 | GTEX | — | 0.845 |
| 9 | SRR819370 | GTEX | — | 0.844 |
| 10 | BS_67Z63A2K | EPN | Posterior Fossa EPN | 0.842 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| CHOLESTEROL_HOMEOSTASIS | 0.254 | Remibrutinib | — uncovered |
| BILE_ACID_METABOLISM | 0.160 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.115 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.105 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.054 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.029 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.012 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.005 | Inavolisib | — uncovered |