Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-CF-A47V-01A-11R-A23W-07

c0b44bed-ab3d-5de8-a850-a8919ba19346

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
12.45072273
os_event
false
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.470
  • ANGIOGENESIS+0.350
  • KRAS_SIGNALING_DN+0.340
  • INTERFERON_GAMMA_RESPONSE+0.290
  • HEDGEHOG_SIGNALING+0.270
  • MYOGENESIS+0.200
  • APICAL_SURFACE+0.180
  • KRAS_SIGNALING_UP+0.170
  • COAGULATION+0.140
  • PANCREAS_BETA_CELLS+0.140

Top 10 suppressed

  • MYC_TARGETS_V1-0.670
  • E2F_TARGETS-0.640
  • G2M_CHECKPOINT-0.620
  • MYC_TARGETS_V2-0.620
  • PROTEIN_SECRETION-0.600
  • UNFOLDED_PROTEIN_RESPONSE-0.560
  • MTORC1_SIGNALING-0.550
  • OXIDATIVE_PHOSPHORYLATION-0.510
  • MITOTIC_SPINDLE-0.440
  • DNA_REPAIR-0.410

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

7 twins match this tumor's tissue · 3 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1BS_0XEG6SNV
medullo-epn-umap@date-based
EPNSupratentorial EPN0.914
2TCGA-75-7025-01A-12R-1949-07
lung-landscapes@6
cohortA10.903
3TCGA-97-A4M5-01A-11R-A24X-07
lung-landscapes@6
cohortA10.903
4SRR1489155
brain-umap@2
GTEX0.902
5MNG690
mng-umap@100
0.898
620040065.TNBC
breast-umap@18
D0.896
7TCGA-86-A4P7-01A-11R-A24X-07
lung-landscapes@6
cohortA10.894
8TCGA-97-A4M7-01A-11R-A24X-07
lung-landscapes@6
cohortA10.894
9BS_GTZCFGRZ
brain-umap@2
Ganglioglioma0.892
10TCGA-49-AARN-01A-21R-A41B-07
lung-landscapes@6
cohortA10.890

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 16 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.470Inavolisib— uncovered
ANGIOGENESIS0.350Remibrutinib— uncovered
KRAS_SIGNALING_DN0.340Remibrutinib— uncovered
INTERFERON_GAMMA_RESPONSE0.290Idelalisib— uncovered
HEDGEHOG_SIGNALING0.270Inavolisib— uncovered
MYOGENESIS0.200Inavolisib— uncovered
APICAL_SURFACE0.180Temsirolimus— uncovered
KRAS_SIGNALING_UP0.170Inavolisib— uncovered
COAGULATION0.140Binimetinib— uncovered
PANCREAS_BETA_CELLS0.140Cobimetinib— uncovered
IL6_JAK_STAT3_SIGNALING0.120Inavolisib— uncovered
P53_PATHWAY0.060Idelalisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.050Inavolisib— uncovered
BILE_ACID_METABOLISM0.040Inavolisib— uncovered
APICAL_JUNCTION0.010Inavolisib— uncovered
NOTCH_SIGNALING0.010Inavolisib— uncovered