Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR1797227

· cohortSC

c4f61c3e-a18d-5361-b664-e102ac227040

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
cohortSC
subtype
cohortSC
age_years
46

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

6 twins match this tumor's tissue · 4 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG730
mng-umap@100
0.785
2MDT-AP-0155
medullo-epn-umap@date-based
MedMedulloblastoma0.776
3MNG601
mng-umap@100
0.744
4R146
bladder-landscape@3
0.740
5DRR168548
bladder-landscape@3
0.739
6DRR168537
bladder-landscape@3
0.738
7MDT-AP-3088
medullo-epn-umap@date-based
MedMedulloblastoma0.733
8SRR1797284
lung-landscapes@6
cohortSC0.731
9MDT-AP-0026
medullo-epn-umap@date-based
MedMedulloblastoma0.727
10BS_KYF0Q0E7
medullo-epn-umap@date-based
MedMedulloblastoma0.726

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 19 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PROTEIN_SECRETION0.420Remibrutinib— uncovered
TGF_BETA_SIGNALING0.340Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.320Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.300Cobimetinib— uncovered
ANDROGEN_RESPONSE0.240Inavolisib— uncovered
UV_RESPONSE_DN0.230Inavolisib— uncovered
ADIPOGENESIS0.200Inavolisib— uncovered
MYC_TARGETS_V10.190Inavolisib— uncovered
DNA_REPAIR0.160Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.160Idelalisib— uncovered
G2M_CHECKPOINT0.130Inavolisib— uncovered
HEME_METABOLISM0.130Temsirolimus— uncovered
MTORC1_SIGNALING0.090Inavolisib— uncovered
APOPTOSIS0.080Idelalisib— uncovered
PEROXISOME0.080Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.070Inavolisib— uncovered
GLYCOLYSIS0.060Inavolisib— uncovered
NOTCH_SIGNALING0.010Inavolisib— uncovered
SPERMATOGENESIS0.010Inavolisib— uncovered