Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · mng-umap@100

MNG601

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d0a53cc7-763f-5cdf-ae33-fe759a0d6c85

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • PROTEIN_SECRETION+0.542
  • TGF_BETA_SIGNALING+0.458
  • ANDROGEN_RESPONSE+0.427
  • UV_RESPONSE_DN+0.402
  • UNFOLDED_PROTEIN_RESPONSE+0.294
  • PANCREAS_BETA_CELLS+0.281
  • MYC_TARGETS_V1+0.259
  • MTORC1_SIGNALING+0.182
  • CHOLESTEROL_HOMEOSTASIS+0.161
  • MITOTIC_SPINDLE+0.152

Top 10 suppressed

  • ALLOGRAFT_REJECTION-0.336
  • MYC_TARGETS_V2-0.308
  • MYOGENESIS-0.277
  • INTERFERON_ALPHA_RESPONSE-0.272
  • WNT_BETA_CATENIN_SIGNALING-0.248
  • APICAL_SURFACE-0.245
  • KRAS_SIGNALING_DN-0.225
  • INTERFERON_GAMMA_RESPONSE-0.205
  • ESTROGEN_RESPONSE_LATE-0.188
  • P53_PATHWAY-0.179

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG636
mng-umap@100
——0.804
2MNG619
mng-umap@100
——0.782
3MNG578
mng-umap@100
——0.752
4SRR1797227
lung-landscapes@6
—cohortSC0.744
5R420
bladder-landscape@3
——0.723
6R322R
bladder-landscape@3
——0.723
7TCGA-BH-A1FM-01A-11R-A13Q-07
breast-umap@18
—B0.723
8MNG730
mng-umap@100
——0.716
9SRR934798
brain-umap@2
——0.716
10ERR2598094
medullo-epn-umap@date-based
fetalfetal0.699

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 20 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PROTEIN_SECRETION0.542Remibrutinib— uncovered
TGF_BETA_SIGNALING0.458Inavolisib— uncovered
ANDROGEN_RESPONSE0.427Inavolisib— uncovered
UV_RESPONSE_DN0.402Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.294Idelalisib— uncovered
PANCREAS_BETA_CELLS0.281Cobimetinib— uncovered
MYC_TARGETS_V10.259Inavolisib— uncovered
MTORC1_SIGNALING0.182Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.161Remibrutinib— uncovered
MITOTIC_SPINDLE0.152Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.130Inavolisib— uncovered
KRAS_SIGNALING_UP0.127Inavolisib— uncovered
HEME_METABOLISM0.112Temsirolimus— uncovered
SPERMATOGENESIS0.059Inavolisib— uncovered
IL2_STAT5_SIGNALING0.051Idelalisib— uncovered
HEDGEHOG_SIGNALING0.040Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.035Inavolisib— uncovered
ANGIOGENESIS0.016Remibrutinib— uncovered
G2M_CHECKPOINT0.007Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.006Inavolisib— uncovered