Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-A7-A26J-01B-02R-A277-07

· D

c60ead63-215a-5c09-8bad-c3743224d34b

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
D
subtype
D
overall_survival_months
21

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • UV_RESPONSE_DN+0.380
  • INTERFERON_ALPHA_RESPONSE+0.350
  • INTERFERON_GAMMA_RESPONSE+0.250
  • MITOTIC_SPINDLE+0.200
  • WNT_BETA_CATENIN_SIGNALING+0.170
  • TGF_BETA_SIGNALING+0.110
  • INFLAMMATORY_RESPONSE+0.080
  • PROTEIN_SECRETION+0.060
  • ANDROGEN_RESPONSE+0.050
  • SPERMATOGENESIS+0.020

Top 10 suppressed

  • MYC_TARGETS_V2-0.650
  • OXIDATIVE_PHOSPHORYLATION-0.560
  • MYC_TARGETS_V1-0.520
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.480
  • CHOLESTEROL_HOMEOSTASIS-0.430
  • MTORC1_SIGNALING-0.430
  • UV_RESPONSE_UP-0.430
  • ADIPOGENESIS-0.410
  • DNA_REPAIR-0.410
  • FATTY_ACID_METABOLISM-0.380

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-AC-A3OD-01B-06R-A22O-07
breast-umap@18
D0.937
2TCGA-AC-A3OD-01A-11R-A21T-07
breast-umap@18
D0.905
3TCGA-A7-A26E-01B-06R-A277-07
breast-umap@18
D0.884
4AUR-AER7-TTP1-A-1-0-R-A741-41
breast-umap@18
D0.869
5TCGA-44-2665-01B-06R-A277-07
lung-landscapes@6
cohortMD20.868
6bae6fdb5-9df3-433c-9a4c-e5c159a62bc6
colon-landscapes@1
0.860
7TCGA-A7-A13E-01B-06R-A277-07
breast-umap@18
D0.859
8TCGA-E2-A15I-01A-21R-A137-07
breast-umap@18
B0.853
9TCGA-AC-A3QQ-01B-06R-A22O-07
breast-umap@18
D0.845
10b8135e73-31c3-49af-b4da-a7ed5f28d68a
colon-landscapes@1
0.844

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 10 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
UV_RESPONSE_DN0.380Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.350Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.250Idelalisib— uncovered
MITOTIC_SPINDLE0.200Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.170Inavolisib— uncovered
TGF_BETA_SIGNALING0.110Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.080Idelalisib— uncovered
PROTEIN_SECRETION0.060Remibrutinib— uncovered
ANDROGEN_RESPONSE0.050Inavolisib— uncovered
SPERMATOGENESIS0.020Inavolisib— uncovered