SRR1478768
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYOGENESIS+0.294
- CHOLESTEROL_HOMEOSTASIS+0.142
- KRAS_SIGNALING_DN+0.133
- FATTY_ACID_METABOLISM+0.129
- MITOTIC_SPINDLE+0.087
- BILE_ACID_METABOLISM+0.084
- APICAL_JUNCTION+0.036
- APICAL_SURFACE-0.007
- HEME_METABOLISM-0.008
- PEROXISOME-0.009
Top 10 suppressed
- IL6_JAK_STAT3_SIGNALING-0.590
- INTERFERON_GAMMA_RESPONSE-0.503
- TNFA_SIGNALING_VIA_NFKB-0.501
- ALLOGRAFT_REJECTION-0.463
- INTERFERON_ALPHA_RESPONSE-0.424
- NOTCH_SIGNALING-0.414
- INFLAMMATORY_RESPONSE-0.402
- HEDGEHOG_SIGNALING-0.397
- APOPTOSIS-0.392
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.366
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1352129 | GTEX | — | 0.900 |
| 2 | SRR1322291 | GTEX | — | 0.890 |
| 3 | SRR615249 | GTEX | — | 0.887 |
| 4 | SRR1516067 | — | — | 0.886 |
| 5 | SRR1404640 | GTEX | — | 0.882 |
| 6 | SRR1453214 | GTEX | — | 0.881 |
| 7 | SRR1333930 | GTEX | — | 0.881 |
| 8 | SRR1413414 | GTEX | — | 0.877 |
| 9 | SRR1328960 | GTEX | — | 0.875 |
| 10 | SRR1479802 | GTEX | — | 0.874 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYOGENESIS | 0.294 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.142 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_DN | 0.133 | Remibrutinib | — uncovered |
| FATTY_ACID_METABOLISM | 0.129 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.087 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.084 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.036 | Inavolisib | — uncovered |