Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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6d2b5716-f1e0-41af-bdc2-0efce35a3f26

c98585f6-2eb6-5785-9cec-e25eca97075d

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Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
128f73ee0-f218-4884-81c6-e6b4ba2fdccd
colon-landscapes@1
0.825
2TCGA-50-6597-01A-11R-1858-07
lung-landscapes@6
cohortA10.822
3MNG445
mng-umap@100
0.814
4TCGA-BH-A6R8-01A-21R-A33J-07
breast-umap@18
B0.804
5TCGA-05-5423-01A-01R-1628-07
lung-landscapes@6
cohortA10.793
6ERR2598330
medullo-epn-umap@date-based
fetalfetal0.789
7TCGA-64-5778-01A-01R-1628-07
lung-landscapes@6
cohortA10.787
8TCGA-CV-A461-01A-41R-A266-07
head-neck@1
0.784
9399e5b76-1d8d-4db9-a186-ffdc2f6e0884
melanoma-umap@29
0.774
10TCGA-62-A46Y-01A-11R-A24H-07
lung-landscapes@6
cohortA10.774

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 14 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.400Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.400Idelalisib— uncovered
BILE_ACID_METABOLISM0.300Inavolisib— uncovered
FATTY_ACID_METABOLISM0.300Inavolisib— uncovered
ADIPOGENESIS0.200Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.200Remibrutinib— uncovered
ALLOGRAFT_REJECTION0.100Idelalisib— uncovered
COAGULATION0.100Binimetinib— uncovered
COMPLEMENT0.100Inavolisib— uncovered
GLYCOLYSIS0.100Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.100Inavolisib— uncovered
PANCREAS_BETA_CELLS0.100Cobimetinib— uncovered
PEROXISOME0.100Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.100Inavolisib— uncovered