TCGA-44-4112-01A-01R-A278-07

— · cohortMD2

c98a695b-db32-5656-95ef-ede8b178a77c

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: cohortMD2
subtype: cohortMD2

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

HTTPException: HTTP Error: Request returned HTTP 429 for HTTP HEAD to 'https://pub-e056b053afc04eec88337b62541f3025.r2.dev/oncoscape/lung-landscapes/6/gsva.parquet' LINE 1: SELECT pathway_library_id, pathway_name, gsva_score FROM read_parquet('https://pub-e056b053afc04eec88337b62541f3025... ^

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

7 twins match this tumor's tissue · 3 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	TCGA-A7-A26E-01A-11R-A277-07 breast-umap@18	—	D	0.781
2	SJEPD030580_D1.RNA-Seq medullo-epn-umap@date-based	EPN	EPN Tumor	0.757
3	TCGA-BL-A0C8-01A-11R-A277-07 bladder-landscape@3	—	—	0.748
4	SJEPD031367_D1.RNA-Seq medullo-epn-umap@date-based	EPN	Anaplastic EPN	0.745
5	TCGA-44-2665-01A-01R-A278-07 lung-landscapes@6	—	cohortMD2	0.724
6	BS_KYF0Q0E7 medullo-epn-umap@date-based	Med	Medulloblastoma	0.714
7	SRR1797227 lung-landscapes@6	—	cohortSC	0.706
8	SRR1516042 bladder-landscape@3	—	—	0.704
9	b503bcc9-714d-40aa-8709-3b4577ce8007 colon-landscapes@1	—	—	0.700
10	R157 bladder-landscape@3	—	—	0.699

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 17 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
PROTEIN_SECRETION	0.450	Remibrutinib	— uncovered
UV_RESPONSE_DN	0.300	Inavolisib	— uncovered
ANDROGEN_RESPONSE	0.240	Inavolisib	— uncovered
TGF_BETA_SIGNALING	0.220	Inavolisib	— uncovered
HEME_METABOLISM	0.180	Temsirolimus	— uncovered
MITOTIC_SPINDLE	0.180	Inavolisib	— uncovered
OXIDATIVE_PHOSPHORYLATION	0.160	Remibrutinib	— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION	0.140	Inavolisib	— uncovered
PI3K_AKT_MTOR_SIGNALING	0.140	Inavolisib	— uncovered
BILE_ACID_METABOLISM	0.100	Inavolisib	— uncovered
PEROXISOME	0.060	Idelalisib	— uncovered
GLYCOLYSIS	0.050	Inavolisib	— uncovered
MYC_TARGETS_V1	0.040	Inavolisib	— uncovered
ADIPOGENESIS	0.030	Inavolisib	— uncovered
NOTCH_SIGNALING	0.030	Inavolisib	— uncovered
KRAS_SIGNALING_UP	0.020	Inavolisib	— uncovered
SPERMATOGENESIS	0.020	Inavolisib	— uncovered