Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · mng-umap@100

MNG478

—

cb067653-5d30-5650-822f-e051dc8da96c

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
—
cancer_type_detailed
—
subtype
—

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • ANGIOGENESIS+0.441
  • OXIDATIVE_PHOSPHORYLATION+0.393
  • ADIPOGENESIS+0.341
  • COAGULATION+0.339
  • WNT_BETA_CATENIN_SIGNALING+0.326
  • FATTY_ACID_METABOLISM+0.312
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.301
  • XENOBIOTIC_METABOLISM+0.300
  • GLYCOLYSIS+0.282
  • ALLOGRAFT_REJECTION+0.262

Top 10 suppressed

  • HEDGEHOG_SIGNALING-0.439
  • TGF_BETA_SIGNALING-0.195
  • G2M_CHECKPOINT-0.191
  • MITOTIC_SPINDLE-0.163
  • PROTEIN_SECRETION-0.156
  • UV_RESPONSE_DN-0.146
  • SPERMATOGENESIS-0.141
  • ANDROGEN_RESPONSE-0.136
  • NOTCH_SIGNALING-0.136
  • ESTROGEN_RESPONSE_EARLY-0.132

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG520
mng-umap@100
——0.791
27dab0af8-ab64-4014-b7b7-bf0df59a1b3a
colon-landscapes@1
——0.740
3MNG1091
mng-umap@100
——0.731
465DAB913-D39C-4AC4-BB1C-10E58914571F
brain-umap@2
——0.719
521f65654-07a2-4b27-b511-2497fa298d0e
colon-landscapes@1
——0.717
6C884FB38-DE5C-48BA-95F1-4ABD2991E833
brain-umap@2
——0.706
7BS_JG9JZTA9
brain-umap@2
low-grade glioma—0.705
8349c48ca-ced2-42db-8a50-ea3293116623
colon-landscapes@1
——0.698
9SRR15030861
colon-landscapes@1
——0.695
10MNG381
mng-umap@100
——0.694

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 35 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ANGIOGENESIS0.441Remibrutinib— uncovered
OXIDATIVE_PHOSPHORYLATION0.393Remibrutinib— uncovered
ADIPOGENESIS0.341Inavolisib— uncovered
COAGULATION0.339Binimetinib— uncovered
WNT_BETA_CATENIN_SIGNALING0.326Inavolisib— uncovered
FATTY_ACID_METABOLISM0.312Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.301Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.300Inavolisib— uncovered
GLYCOLYSIS0.282Inavolisib— uncovered
ALLOGRAFT_REJECTION0.262Idelalisib— uncovered
COMPLEMENT0.249Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.246Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.244Inavolisib— uncovered
DNA_REPAIR0.240Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.218Inavolisib— uncovered
APICAL_SURFACE0.213Temsirolimus— uncovered
MYOGENESIS0.210Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.206Idelalisib— uncovered
MYC_TARGETS_V20.205Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.163Inavolisib— uncovered