SRR934765
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- G2M_CHECKPOINT+0.703
- E2F_TARGETS+0.671
- MYC_TARGETS_V1+0.598
- MYC_TARGETS_V2+0.590
- MITOTIC_SPINDLE+0.486
- WNT_BETA_CATENIN_SIGNALING+0.434
- HEDGEHOG_SIGNALING+0.368
- DNA_REPAIR+0.359
- UNFOLDED_PROTEIN_RESPONSE+0.344
- NOTCH_SIGNALING+0.284
Top 10 suppressed
- IL6_JAK_STAT3_SIGNALING-0.488
- BILE_ACID_METABOLISM-0.407
- TNFA_SIGNALING_VIA_NFKB-0.393
- COAGULATION-0.384
- INTERFERON_GAMMA_RESPONSE-0.376
- XENOBIOTIC_METABOLISM-0.371
- IL2_STAT5_SIGNALING-0.369
- INTERFERON_ALPHA_RESPONSE-0.368
- INFLAMMATORY_RESPONSE-0.366
- COMPLEMENT-0.355
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | ERR2598226 | fetal | fetal | 0.929 |
| 2 | 4938761D-0762-4984-A399-BC036D6D2140 | — | — | 0.928 |
| 3 | E528D9EE-41C3-4D4C-B16F-ABBDD6E31B84 | — | — | 0.924 |
| 4 | ERR2598195 | fetal | fetal | 0.922 |
| 5 | ERR2598206 | fetal | fetal | 0.917 |
| 6 | SRR934937 | — | — | 0.912 |
| 7 | 848C73F3-ABD7-47FD-BF70-FF29FBDF6F61 | — | — | 0.909 |
| 8 | CA366342-0949-4941-8AE6-984BAF032886 | — | — | 0.906 |
| 9 | E3A67B7B-7427-4C11-912B-166451072767 | — | — | 0.904 |
| 10 | 2B4FA61A-C1A7-49BD-9438-2865D386EAF2 | — | — | 0.902 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 19 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| G2M_CHECKPOINT | 0.703 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.671 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.598 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.590 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.486 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.434 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.368 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.359 | Idelalisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.344 | Idelalisib | — uncovered |
| NOTCH_SIGNALING | 0.284 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.225 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.173 | Remibrutinib | — uncovered |
| TGF_BETA_SIGNALING | 0.136 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.130 | Cobimetinib | — uncovered |
| UV_RESPONSE_DN | 0.070 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.068 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.043 | Inavolisib | — uncovered |
| GLYCOLYSIS | 0.034 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.017 | Idelalisib | — uncovered |