Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

E3A67B7B-7427-4C11-912B-166451072767

e1576935-923c-5617-8f53-d961c957dc4d

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
14.388961892247043
age_years
65
sex
Female

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
12C70D7BF-85C4-447B-B0F9-A129D6B49E77
brain-umap@2
0.951
2A85A0E3A-2CB9-40EB-80E9-125EC137151B
brain-umap@2
0.948
3ERR2598102
medullo-epn-umap@date-based
fetalfetal0.941
410FB7E59-9D71-4AB9-8D06-9CFD2304D1BC
brain-umap@2
0.937
5332283CB-F855-4493-A259-7852FD37B9DC
brain-umap@2
0.936
6713B4DA5-FA8A-4E52-BACF-19B912467FBB
brain-umap@2
0.933
7ERR2598229
medullo-epn-umap@date-based
fetalfetal0.932
8CB9E4206-E2F7-49EA-8FB2-E69E5BB3B018
brain-umap@2
0.928
9TCGA-22-5477-01A-01R-1635-07
lung-landscapes@6
cohortSQ20.927
107DC6D598-8506-4680-81DF-C1D0F1B5C27D
brain-umap@2
0.927

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 24 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
E2F_TARGETS0.677Inavolisib— uncovered
G2M_CHECKPOINT0.646Inavolisib— uncovered
MYC_TARGETS_V10.596Inavolisib— uncovered
MYC_TARGETS_V20.552Idelalisib— uncovered
MITOTIC_SPINDLE0.474Inavolisib— uncovered
DNA_REPAIR0.464Idelalisib— uncovered
PROTEIN_SECRETION0.352Remibrutinib— uncovered
MTORC1_SIGNALING0.338Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.335Remibrutinib— uncovered
OXIDATIVE_PHOSPHORYLATION0.321Remibrutinib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.308Idelalisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.289Inavolisib— uncovered
HEDGEHOG_SIGNALING0.223Inavolisib— uncovered
ANDROGEN_RESPONSE0.220Inavolisib— uncovered
NOTCH_SIGNALING0.186Inavolisib— uncovered
UV_RESPONSE_DN0.127Inavolisib— uncovered
TGF_BETA_SIGNALING0.096Inavolisib— uncovered
PEROXISOME0.095Idelalisib— uncovered
PANCREAS_BETA_CELLS0.089Cobimetinib— uncovered
UV_RESPONSE_UP0.063Idelalisib— uncovered