sclc0624_S64.txt
— · cohortSC
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortSC
- subtype
- cohortSC
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.520
- SPERMATOGENESIS+0.290
- MYC_TARGETS_V1+0.250
- KRAS_SIGNALING_DN+0.210
- HEME_METABOLISM+0.100
- E2F_TARGETS+0.050
- BILE_ACID_METABOLISM+0.020
- OXIDATIVE_PHOSPHORYLATION+0.020
- G2M_CHECKPOINT-0.030
- FATTY_ACID_METABOLISM-0.050
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.500
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.490
- INTERFERON_GAMMA_RESPONSE-0.460
- TGF_BETA_SIGNALING-0.440
- NOTCH_SIGNALING-0.400
- CHOLESTEROL_HOMEOSTASIS-0.370
- IL6_JAK_STAT3_SIGNALING-0.370
- TNFA_SIGNALING_VIA_NFKB-0.370
- UV_RESPONSE_DN-0.370
- UNFOLDED_PROTEIN_RESPONSE-0.360
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR10900563 | — | — | 0.896 |
| 2 | SRR1797262 | — | cohortSC | 0.883 |
| 3 | TCGA-BB-4224-01A-01R-1436-07 | — | — | 0.879 |
| 4 | SRR12696792 | — | — | 0.877 |
| 5 | SRR934734 | — | — | 0.866 |
| 6 | SRR10842347 | — | — | 0.865 |
| 7 | TCGA-E7-A7PW-01A-11R-A352-07 | — | — | 0.863 |
| 8 | sclcD1531109_S55.txt | — | cohortSC | 0.857 |
| 9 | SRR934740 | — | — | 0.850 |
| 10 | SRR26320083 | — | — | 0.849 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.520 | Cobimetinib | — uncovered |
| SPERMATOGENESIS | 0.290 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.250 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.210 | Remibrutinib | — uncovered |
| HEME_METABOLISM | 0.100 | Temsirolimus | — uncovered |
| E2F_TARGETS | 0.050 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.020 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.020 | Remibrutinib | — uncovered |