MNG1047
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- ALLOGRAFT_REJECTION+0.401
- TGF_BETA_SIGNALING+0.315
- INTERFERON_GAMMA_RESPONSE+0.253
- ADIPOGENESIS+0.250
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.238
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.236
- PI3K_AKT_MTOR_SIGNALING+0.221
- OXIDATIVE_PHOSPHORYLATION+0.215
- PROTEIN_SECRETION+0.196
- INFLAMMATORY_RESPONSE+0.191
Top 10 suppressed
- G2M_CHECKPOINT-0.363
- E2F_TARGETS-0.350
- PANCREAS_BETA_CELLS-0.284
- SPERMATOGENESIS-0.216
- KRAS_SIGNALING_DN-0.196
- MYC_TARGETS_V2-0.176
- ANGIOGENESIS-0.138
- TNFA_SIGNALING_VIA_NFKB-0.110
- ESTROGEN_RESPONSE_LATE-0.088
- BILE_ACID_METABOLISM-0.081
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG1046 | — | — | 0.761 |
| 2 | MNG1182 | — | — | 0.759 |
| 3 | MNG1019 | — | — | 0.752 |
| 4 | SRR26320064 | — | — | 0.743 |
| 5 | MNG1060 | — | — | 0.740 |
| 6 | BS_SHMC4902 | pilocytic astrocytoma | — | 0.729 |
| 7 | MNG980 | — | — | 0.721 |
| 8 | MNG985 | — | — | 0.719 |
| 9 | BS_ZZWMD6FA | Ganglioglioma | — | 0.708 |
| 10 | BS_E0N3PTPN | pleomorphic xanthoastrocytoma(PXA) | — | 0.708 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 31 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| ALLOGRAFT_REJECTION | 0.401 | Idelalisib | — uncovered |
| TGF_BETA_SIGNALING | 0.315 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.253 | Idelalisib | — uncovered |
| ADIPOGENESIS | 0.250 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.238 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.236 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.221 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.215 | Remibrutinib | — uncovered |
| PROTEIN_SECRETION | 0.196 | Remibrutinib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.191 | Idelalisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.190 | Inavolisib | — uncovered |
| MYOGENESIS | 0.165 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.162 | Idelalisib | — uncovered |
| KRAS_SIGNALING_UP | 0.162 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.161 | Inavolisib | — uncovered |
| APOPTOSIS | 0.134 | Idelalisib | — uncovered |
| COMPLEMENT | 0.130 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.128 | Idelalisib | — uncovered |
| IL2_STAT5_SIGNALING | 0.124 | Idelalisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.104 | Inavolisib | — uncovered |