08e3d239-3d8a-4eee-9e08-ac2bcb3f2619
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.400
- PANCREAS_BETA_CELLS+0.300
- SPERMATOGENESIS+0.300
- COAGULATION+0.000
- MYOGENESIS+0.000
- APICAL_SURFACE-0.100
- BILE_ACID_METABOLISM-0.100
- ESTROGEN_RESPONSE_LATE-0.100
- KRAS_SIGNALING_UP-0.100
- ALLOGRAFT_REJECTION-0.200
Top 10 suppressed
- MYC_TARGETS_V1-0.700
- DNA_REPAIR-0.600
- MITOTIC_SPINDLE-0.600
- MTORC1_SIGNALING-0.600
- MYC_TARGETS_V2-0.600
- OXIDATIVE_PHOSPHORYLATION-0.600
- PROTEIN_SECRETION-0.600
- UNFOLDED_PROTEIN_RESPONSE-0.600
- ADIPOGENESIS-0.500
- ANDROGEN_RESPONSE-0.500
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG597 | — | — | 0.990 |
| 2 | TCGA-CF-A3MF-01A-12R-A21D-07 | — | — | 0.985 |
| 3 | c7d31245-5d71-4a23-8a33-4f83c4718e20 | — | — | 0.984 |
| 4 | MNG1246 | — | — | 0.983 |
| 5 | MNG598 | — | — | 0.982 |
| 6 | 8ad884fa-e426-4bc0-960d-08db42d341da | — | — | 0.982 |
| 7 | msclc569389_S35.txt | — | cohortMD1 | 0.980 |
| 8 | MNG1259 | — | — | 0.979 |
| 9 | SRR12696761 | — | — | 0.978 |
| 10 | SRR1366141 | GTEX | — | 0.978 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 3 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.400 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.300 | Cobimetinib | — uncovered |
| SPERMATOGENESIS | 0.300 | Inavolisib | — uncovered |