Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-44-3919-01A-02R-1107-07

· cohortA1

d36824e2-47dc-5b8e-bb0e-aad4d14230bb

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
cohortA1
subtype
cohortA1
age_years
71

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
12d12ea90-c4f4-4aca-b353-360057b446e2
melanoma-umap@29
0.906
2TCGA-97-A4LX-01A-11R-A24X-07
lung-landscapes@6
cohortA10.863
3TCGA-97-A4M6-01A-11R-A24X-07
lung-landscapes@6
cohortA10.863
4DRR168552
bladder-landscape@3
0.862
5TCGA-44-2657-01A-01R-1107-07
lung-landscapes@6
cohortA10.857
6TCGA-95-8039-01A-11R-2241-07
lung-landscapes@6
cohortA10.854
7SRR1375952
brain-umap@2
GTEX0.853
8BS_CS170P7T
brain-umap@2
pilocytic astrocytoma0.852
920030005.Her2HRpos
breast-umap@18
A0.849
10TCGA-MP-A4TJ-01A-51R-A262-07
lung-landscapes@6
cohortA10.847

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 18 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.670Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.540Idelalisib— uncovered
ALLOGRAFT_REJECTION0.460Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.430Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.350Idelalisib— uncovered
COMPLEMENT0.310Inavolisib— uncovered
KRAS_SIGNALING_UP0.270Inavolisib— uncovered
IL2_STAT5_SIGNALING0.250Idelalisib— uncovered
BILE_ACID_METABOLISM0.230Inavolisib— uncovered
HEME_METABOLISM0.190Temsirolimus— uncovered
COAGULATION0.150Binimetinib— uncovered
TGF_BETA_SIGNALING0.140Inavolisib— uncovered
APOPTOSIS0.120Idelalisib— uncovered
NOTCH_SIGNALING0.120Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.090Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.060Inavolisib— uncovered
APICAL_SURFACE0.050Temsirolimus— uncovered
ESTROGEN_RESPONSE_LATE0.030Idelalisib— uncovered