Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · brain-umap@2

BS_R244Z0WX

pilocytic astrocytoma

d45f5384-8f2b-598f-aa1e-fc3cb70cc641

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
pilocytic astrocytoma
cancer_type_detailed
—
subtype
—
cancer_type
pilocytic astrocytoma
age_years
20.786
sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • IL6_JAK_STAT3_SIGNALING+0.421
  • INFLAMMATORY_RESPONSE+0.418
  • ALLOGRAFT_REJECTION+0.398
  • INTERFERON_ALPHA_RESPONSE+0.388
  • INTERFERON_GAMMA_RESPONSE+0.371
  • MYOGENESIS+0.368
  • KRAS_SIGNALING_DN+0.334
  • COAGULATION+0.319
  • APICAL_SURFACE+0.300
  • BILE_ACID_METABOLISM+0.294

Top 10 suppressed

  • MYC_TARGETS_V1-0.651
  • E2F_TARGETS-0.602
  • G2M_CHECKPOINT-0.580
  • OXIDATIVE_PHOSPHORYLATION-0.569
  • MYC_TARGETS_V2-0.565
  • UNFOLDED_PROTEIN_RESPONSE-0.538
  • MTORC1_SIGNALING-0.442
  • DNA_REPAIR-0.427
  • PROTEIN_SECRETION-0.405
  • MITOTIC_SPINDLE-0.283

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-55-8619-01A-11R-2403-07
lung-landscapes@6
—cohortA10.950
2TCGA-56-8623-01A-11R-A28V-07
lung-landscapes@6
—cohortA10.947
3a802b49c.736d.427c.bcca.8375c4171284
lung-landscapes@6
—cohortA10.945
4TCGA-38-A44F-01A-11R-A24H-07
lung-landscapes@6
—cohortA10.939
5BS_NPQJ20KX
brain-umap@2
pilocytic astrocytoma—0.933
6TCGA-69-8453-01A-12R-2326-07
lung-landscapes@6
—cohortA10.930
7MDT-AP-1152
medullo-epn-umap@date-based
MedMedulloblastoma0.930
8TCGA-99-AA5R-01A-11R-A39D-07
lung-landscapes@6
—cohortA10.928
9TCGA-L4-A4E6-01A-11R-A24H-07
lung-landscapes@6
—cohortA10.927
10BS_BA6AZWB3
medullo-epn-umap@date-based
MedMedulloblastoma0.926

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 29 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
IL6_JAK_STAT3_SIGNALING0.421Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.418Idelalisib— uncovered
ALLOGRAFT_REJECTION0.398Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.388Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.371Idelalisib— uncovered
MYOGENESIS0.368Inavolisib— uncovered
KRAS_SIGNALING_DN0.334Remibrutinib— uncovered
COAGULATION0.319Binimetinib— uncovered
APICAL_SURFACE0.300Temsirolimus— uncovered
BILE_ACID_METABOLISM0.294Inavolisib— uncovered
KRAS_SIGNALING_UP0.267Inavolisib— uncovered
COMPLEMENT0.250Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.235Inavolisib— uncovered
IL2_STAT5_SIGNALING0.235Idelalisib— uncovered
P53_PATHWAY0.227Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.226Inavolisib— uncovered
NOTCH_SIGNALING0.225Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.177Inavolisib— uncovered
APICAL_JUNCTION0.150Inavolisib— uncovered
PANCREAS_BETA_CELLS0.141Cobimetinib— uncovered