MNG559

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d57a61bf-afec-55f4-966b-cd1557a2dfa9

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: —

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

7 twins match this tumor's tissue · 3 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	SJEPD001534_D1.RNA-Seq medullo-epn-umap@date-based	EPN	Posterior Fossa EPN	0.874
2	f17e12f0-54ed-4dc2-ab7e-22a1f90e1405 colon-landscapes@1	—	—	0.864
3	SRR6079989 head-neck@1	—	—	0.862
4	c2e34dda-0852-492e-9cde-3ff606259c12 melanoma-umap@29	—	—	0.855
5	SJEPD001524_R1.RNA-Seq medullo-epn-umap@date-based	EPN	Posterior Fossa EPN	0.846
6	MNG656 mng-umap@100	—	—	0.839
7	SRR23303730 bladder-landscape@3	—	—	0.835
8	TCGA-AC-A3TN-01A-11R-A22K-07 breast-umap@18	—	B	0.831
9	SJEPD001520_D1.RNA-Seq medullo-epn-umap@date-based	EPN	Posterior Fossa EPN	0.824
10	R88 bladder-landscape@3	—	—	0.816

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 18 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
MYOGENESIS	0.301	Inavolisib	— uncovered
KRAS_SIGNALING_DN	0.257	Remibrutinib	— uncovered
APICAL_SURFACE	0.236	Temsirolimus	— uncovered
COAGULATION	0.214	Binimetinib	— uncovered
APICAL_JUNCTION	0.160	Inavolisib	— uncovered
WNT_BETA_CATENIN_SIGNALING	0.158	Inavolisib	— uncovered
XENOBIOTIC_METABOLISM	0.154	Inavolisib	— uncovered
DNA_REPAIR	0.090	Idelalisib	— uncovered
UV_RESPONSE_UP	0.089	Idelalisib	— uncovered
CHOLESTEROL_HOMEOSTASIS	0.071	Remibrutinib	— uncovered
MYC_TARGETS_V2	0.069	Idelalisib	— uncovered
PEROXISOME	0.058	Idelalisib	— uncovered
P53_PATHWAY	0.047	Idelalisib	— uncovered
NOTCH_SIGNALING	0.046	Inavolisib	— uncovered
ESTROGEN_RESPONSE_LATE	0.043	Idelalisib	— uncovered
ESTROGEN_RESPONSE_EARLY	0.037	Inavolisib	— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY	0.014	Inavolisib	— uncovered
BILE_ACID_METABOLISM	0.011	Inavolisib	— uncovered