MNG656
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYOGENESIS+0.205
- P53_PATHWAY+0.192
- KRAS_SIGNALING_DN+0.163
- DNA_REPAIR+0.152
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.134
- APICAL_SURFACE+0.094
- APICAL_JUNCTION+0.060
- NOTCH_SIGNALING+0.033
- WNT_BETA_CATENIN_SIGNALING-0.003
- HYPOXIA-0.008
Top 10 suppressed
- PROTEIN_SECRETION-0.565
- MYC_TARGETS_V1-0.445
- ANDROGEN_RESPONSE-0.436
- G2M_CHECKPOINT-0.415
- UV_RESPONSE_DN-0.376
- MTORC1_SIGNALING-0.367
- E2F_TARGETS-0.335
- UNFOLDED_PROTEIN_RESPONSE-0.322
- CHOLESTEROL_HOMEOSTASIS-0.306
- OXIDATIVE_PHOSPHORYLATION-0.242
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_A87NPZAP | Med | Medulloblastoma | 0.887 |
| 2 | R76 | — | — | 0.857 |
| 3 | TCGA-D8-A3Z5-01A-41R-A24H-07 | — | A | 0.851 |
| 4 | R71 | — | — | 0.848 |
| 5 | TCGA-A2-A0CK-01A-11R-A22K-07 | — | A | 0.846 |
| 6 | MNG1250 | — | — | 0.845 |
| 7 | MNG559 | — | — | 0.839 |
| 8 | MNG1258 | — | — | 0.832 |
| 9 | TCGA-W8-A86G-01A-21R-A36F-07 | — | A | 0.832 |
| 10 | df6cc1d8-c28f-4530-95ff-4e18ee383e88 | — | — | 0.831 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYOGENESIS | 0.205 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.192 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.163 | Remibrutinib | — uncovered |
| DNA_REPAIR | 0.152 | Idelalisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.134 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.094 | Temsirolimus | — uncovered |
| APICAL_JUNCTION | 0.060 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.033 | Inavolisib | — uncovered |