Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
KIRhub 2.0
Sign in

83a1d91a-3e74-4106-96d1-eec558404c29

d5f1b94a-5f35-5e93-8442-21c340397e15

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
age_years
70

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • E2F_TARGETS+0.530
  • G2M_CHECKPOINT+0.520
  • MYC_TARGETS_V2+0.460
  • ALLOGRAFT_REJECTION+0.380
  • MYC_TARGETS_V1+0.380
  • MTORC1_SIGNALING+0.340
  • INTERFERON_GAMMA_RESPONSE+0.310
  • SPERMATOGENESIS+0.300
  • INTERFERON_ALPHA_RESPONSE+0.280
  • MITOTIC_SPINDLE+0.250

Top 10 suppressed

  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.460
  • ANGIOGENESIS-0.450
  • COAGULATION-0.390
  • MYOGENESIS-0.390
  • APICAL_JUNCTION-0.300
  • PROTEIN_SECRETION-0.280
  • OXIDATIVE_PHOSPHORYLATION-0.260
  • FATTY_ACID_METABOLISM-0.240
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.220
  • P53_PATHWAY-0.210

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MBCProject_1819_T1_RNA
breast-umap@18
C0.844
2TCGA-BH-A1FC-01A-11R-A13Q-07
breast-umap@18
E0.838
3SRR10900596
melanoma-umap@29
0.829
4SRR5088891
melanoma-umap@29
0.821
5TCGA-CN-A499-01A-11R-A24H-07
head-neck@1
0.799
6TCGA-GM-A2DH-01A-11R-A180-07
breast-umap@18
C0.788
7TCGA-E2-A1L7-01A-11R-A144-07
breast-umap@18
C0.787
8d708a0d7-edda-46a8-b717-1b48c073c828
melanoma-umap@29
0.787
9MBCproject_0095_T3_RNA
breast-umap@18
E0.786
10TCGA-E2-A1LI-01A-12R-A157-07
breast-umap@18
E0.783