Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-69-7978-01A-11R-2187-07

· cohortA1

d8048100-62de-58f4-8fcf-4979a5f85eec

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
cohortA1
subtype
cohortA1
age_years
59

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-63-A5MN-01A-22R-A27Q-07
lung-landscapes@6
cohortA10.944
2cf9ea065-c101-48e2-a1ea-54eb01658eef
melanoma-umap@29
0.903
3TCGA-A8-A096-01A-11R-A00Z-07
breast-umap@18
B0.895
46bf9821d-da67-470f-9650-69d05b056166
melanoma-umap@29
0.894
5TCGA-55-6971-01A-11R-1949-07
lung-landscapes@6
cohortMD20.889
6TCGA-55-6712-01A-11R-1858-07
lung-landscapes@6
cohortA10.886
7SRR10900557
melanoma-umap@29
0.885
8SRR5088879
melanoma-umap@29
0.885
9b02dc7a2-3615-4b6c-a3dd-a866d8561d9d
colon-landscapes@1
0.885
10d719788d-0c64-4488-bb84-ab5536d31a03
colon-landscapes@1
0.884

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 25 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.580Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.580Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.550Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.510Inavolisib— uncovered
COMPLEMENT0.470Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.450Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.410Inavolisib— uncovered
IL2_STAT5_SIGNALING0.380Idelalisib— uncovered
UV_RESPONSE_DN0.360Inavolisib— uncovered
ANGIOGENESIS0.350Remibrutinib— uncovered
KRAS_SIGNALING_UP0.350Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.350Inavolisib— uncovered
TGF_BETA_SIGNALING0.330Inavolisib— uncovered
MITOTIC_SPINDLE0.270Inavolisib— uncovered
HYPOXIA0.260Idelalisib— uncovered
APOPTOSIS0.240Idelalisib— uncovered
APICAL_JUNCTION0.210Inavolisib— uncovered
NOTCH_SIGNALING0.210Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.190Inavolisib— uncovered
PROTEIN_SECRETION0.180Remibrutinib— uncovered