TCGA-OR-A5JS-01
Adrenocortical Carcinoma · Adrenocortical Carcinoma · Adrenocortical Carcinoma, Usual Type
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- Adrenocortical Carcinoma
- cancer_type_detailed
- Adrenocortical Carcinoma
- subtype
- Adrenocortical Carcinoma, Usual Type
- cancer_type
- Adrenocortical Carcinoma
- cancer_type_detailed
- Adrenocortical Carcinoma
- subtype
- Adrenocortical Carcinoma, Usual Type
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- E2F_TARGETS+0.419
- G2M_CHECKPOINT+0.400
- CHOLESTEROL_HOMEOSTASIS+0.364
- MTORC1_SIGNALING+0.341
- UV_RESPONSE_UP+0.195
- UNFOLDED_PROTEIN_RESPONSE+0.194
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.190
- TNFA_SIGNALING_VIA_NFKB+0.188
- SPERMATOGENESIS+0.178
- MYC_TARGETS_V2+0.161
Top 10 suppressed
- ALLOGRAFT_REJECTION-0.309
- COAGULATION-0.259
- INTERFERON_GAMMA_RESPONSE-0.252
- COMPLEMENT-0.233
- UV_RESPONSE_DN-0.222
- OXIDATIVE_PHOSPHORYLATION-0.217
- HEDGEHOG_SIGNALING-0.215
- PI3K_AKT_MTOR_SIGNALING-0.189
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.185
- INTERFERON_ALPHA_RESPONSE-0.174
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | 6bc5d616-670c-4778-a769-d5b64fc51d8e | — | — | 0.781 |
| 2 | 53fd72a0-30b5-4488-afb2-e77c2fd6a0d4 | — | — | 0.756 |
| 3 | SRR26320071 | — | — | 0.756 |
| 4 | SRR5088814 | — | — | 0.755 |
| 5 | e235012b-4b29-478a-abad-6a70cd949cfa | — | — | 0.748 |
| 6 | a1539e2f-42d6-4314-9ea0-e29635d9e76f | — | — | 0.742 |
| 7 | SRR2932844 | — | — | 0.737 |
| 8 | MNG1229 | — | — | 0.733 |
| 9 | TCGA-77-6845-01A-11R-1949-07 | — | cohortSQ2 | 0.730 |
| 10 | TCGA-85-8354-01A-31R-2326-07 | — | cohortSQ2 | 0.729 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 25 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| E2F_TARGETS | 0.419 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.400 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.364 | Remibrutinib | — uncovered |
| MTORC1_SIGNALING | 0.341 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.195 | Idelalisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.194 | Idelalisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.190 | Inavolisib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.188 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.178 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.161 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.148 | Idelalisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.148 | Inavolisib | — uncovered |
| PEROXISOME | 0.143 | Idelalisib | — uncovered |
| ANDROGEN_RESPONSE | 0.142 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.139 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.095 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.086 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.082 | Idelalisib | — uncovered |
| HYPOXIA | 0.073 | Idelalisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.072 | Inavolisib | — uncovered |