C3N-01016
— · cohortA3
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortA3
- subtype
- cohortA3
- age_years
- 56.91170431
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.300
- E2F_TARGETS+0.290
- G2M_CHECKPOINT+0.290
- UNFOLDED_PROTEIN_RESPONSE+0.270
- ANDROGEN_RESPONSE+0.210
- SPERMATOGENESIS+0.180
- PROTEIN_SECRETION+0.160
- TGF_BETA_SIGNALING+0.100
- UV_RESPONSE_DN+0.070
- MTORC1_SIGNALING+0.030
Top 10 suppressed
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.410
- ALLOGRAFT_REJECTION-0.400
- OXIDATIVE_PHOSPHORYLATION-0.380
- P53_PATHWAY-0.380
- APICAL_JUNCTION-0.350
- APICAL_SURFACE-0.350
- IL6_JAK_STAT3_SIGNALING-0.310
- DNA_REPAIR-0.290
- ADIPOGENESIS-0.280
- INFLAMMATORY_RESPONSE-0.280
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SJEPD031786_D2.RNA-Seq | EPN | Anaplastic EPN | 0.823 |
| 2 | ERR2598094 | fetal | fetal | 0.815 |
| 3 | s0122214 | — | — | 0.807 |
| 4 | TCGA-AO-A1KS-01A-11R-A13Q-07 | — | B | 0.801 |
| 5 | SRR12202470 | — | — | 0.792 |
| 6 | b503bcc9-714d-40aa-8709-3b4577ce8007 | — | — | 0.789 |
| 7 | SRR12202467 | — | — | 0.787 |
| 8 | SRR5088922 | — | — | 0.782 |
| 9 | MNG640 | — | — | 0.781 |
| 10 | a277c487-2d13-460f-a0d8-26acac1657d0 | — | — | 0.780 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.300 | Cobimetinib | — uncovered |
| E2F_TARGETS | 0.290 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.290 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.270 | Idelalisib | — uncovered |
| ANDROGEN_RESPONSE | 0.210 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.180 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.160 | Remibrutinib | — uncovered |
| TGF_BETA_SIGNALING | 0.100 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.070 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.030 | Inavolisib | — uncovered |