Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

AUR-AFUG-TTM1-A-1-1-R-A743-41

· C

da474aef-8fb3-5601-ba08-04332aaa303a

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
C
subtype
C

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

HTTPException: HTTP Error: HTTP GET error on 'https://pub-e056b053afc04eec88337b62541f3025.r2.dev/oncoscape/breast-umap/18/gsva.parquet' (HTTP 429 Too Many Requests)

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

7 twins match this tumor's tissue · 3 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1AUR-AE5G-TTP1-A-1-1-R-A742-41
breast-umap@18
C0.864
2MDT-AP-0118
medullo-epn-umap@date-based
MedMedulloblastoma0.838
3MDT-AP-2390
medullo-epn-umap@date-based
MedMedulloblastoma0.836
4AE47BCDE-A2D2-43EF-8EC7-78E4D1817EEE
brain-umap@2
0.818
5MDT-AP-2377
medullo-epn-umap@date-based
MedMedulloblastoma0.811
6TCGA-60-2725-01A-01R-1201-07
lung-landscapes@6
cohortSQ10.810
7SRR934877
brain-umap@2
0.809
8BDBF3ACE-7DC0-47C1-9B03-E2EDCF0B6CE6
brain-umap@2
0.806
9MBCProject_0734_T1B_RNA
breast-umap@18
C0.804
10TCGA-FD-A5C1-01A-11R-A28M-07
bladder-landscape@3
0.804

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 39 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.590Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.540Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.480Idelalisib— uncovered
ANGIOGENESIS0.420Remibrutinib— uncovered
ALLOGRAFT_REJECTION0.410Idelalisib— uncovered
E2F_TARGETS0.400Inavolisib— uncovered
COAGULATION0.390Binimetinib— uncovered
PANCREAS_BETA_CELLS0.370Cobimetinib— uncovered
PROTEIN_SECRETION0.370Remibrutinib— uncovered
MYC_TARGETS_V10.350Inavolisib— uncovered
KRAS_SIGNALING_UP0.330Inavolisib— uncovered
COMPLEMENT0.320Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.310Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.300Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.300Idelalisib— uncovered
APOPTOSIS0.270Idelalisib— uncovered
IL2_STAT5_SIGNALING0.270Idelalisib— uncovered
DNA_REPAIR0.250Idelalisib— uncovered
MTORC1_SIGNALING0.250Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.240Remibrutinib— uncovered