SRR1396640
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.500
- PANCREAS_BETA_CELLS+0.446
- HEDGEHOG_SIGNALING+0.315
- ESTROGEN_RESPONSE_EARLY+0.298
- ESTROGEN_RESPONSE_LATE+0.256
- MYOGENESIS+0.223
- BILE_ACID_METABOLISM+0.190
- SPERMATOGENESIS+0.184
- UV_RESPONSE_DN+0.173
- WNT_BETA_CATENIN_SIGNALING+0.157
Top 10 suppressed
- MYC_TARGETS_V1-0.668
- UNFOLDED_PROTEIN_RESPONSE-0.541
- E2F_TARGETS-0.531
- MYC_TARGETS_V2-0.499
- PROTEIN_SECRETION-0.496
- DNA_REPAIR-0.491
- OXIDATIVE_PHOSPHORYLATION-0.442
- MTORC1_SIGNALING-0.441
- G2M_CHECKPOINT-0.430
- INTERFERON_ALPHA_RESPONSE-0.390
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1331751 | GTEX | — | 0.964 |
| 2 | SRR1471350 | GTEX | — | 0.953 |
| 3 | SRR1337909 | GTEX | — | 0.946 |
| 4 | SRR1337864 | GTEX | — | 0.945 |
| 5 | SRR1485542 | GTEX | — | 0.944 |
| 6 | SRR1311575 | GTEX | — | 0.943 |
| 7 | SRR1352975 | GTEX | — | 0.942 |
| 8 | SRR1314958 | GTEX | — | 0.942 |
| 9 | SRR1500868 | GTEX | — | 0.940 |
| 10 | SRR1431307 | GTEX | — | 0.938 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 15 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.500 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.446 | Cobimetinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.315 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.298 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.256 | Idelalisib | — uncovered |
| MYOGENESIS | 0.223 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.190 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.184 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.173 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.157 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.154 | Temsirolimus | — uncovered |
| APICAL_JUNCTION | 0.135 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.057 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.052 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.039 | Inavolisib | — uncovered |