SRR1337909
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.411
- KRAS_SIGNALING_DN+0.341
- HEDGEHOG_SIGNALING+0.259
- UV_RESPONSE_DN+0.130
- MYOGENESIS+0.123
- SPERMATOGENESIS+0.120
- NOTCH_SIGNALING+0.098
- ESTROGEN_RESPONSE_LATE+0.082
- BILE_ACID_METABOLISM+0.073
- WNT_BETA_CATENIN_SIGNALING+0.054
Top 10 suppressed
- MYC_TARGETS_V1-0.624
- MYC_TARGETS_V2-0.552
- IL6_JAK_STAT3_SIGNALING-0.528
- E2F_TARGETS-0.502
- UNFOLDED_PROTEIN_RESPONSE-0.474
- PROTEIN_SECRETION-0.466
- TNFA_SIGNALING_VIA_NFKB-0.461
- G2M_CHECKPOINT-0.445
- ALLOGRAFT_REJECTION-0.438
- MTORC1_SIGNALING-0.425
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1500868 | GTEX | — | 0.969 |
| 2 | SRR1431307 | GTEX | — | 0.962 |
| 3 | SRR1388378 | GTEX | — | 0.959 |
| 4 | SRR1485542 | GTEX | — | 0.959 |
| 5 | SRR1471350 | GTEX | — | 0.958 |
| 6 | SRR1488672 | GTEX | — | 0.958 |
| 7 | SRR1477080 | GTEX | — | 0.956 |
| 8 | SRR1341277 | GTEX | — | 0.954 |
| 9 | SRR1396640 | GTEX | — | 0.946 |
| 10 | SRR1315269 | GTEX | — | 0.944 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 12 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.411 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.341 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.259 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.130 | Inavolisib | — uncovered |
| MYOGENESIS | 0.123 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.120 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.098 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.082 | Idelalisib | — uncovered |
| BILE_ACID_METABOLISM | 0.073 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.054 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.031 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.026 | Temsirolimus | — uncovered |