SRR1486741
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- DNA_REPAIR+0.121
- KRAS_SIGNALING_DN+0.024
- MITOTIC_SPINDLE+0.020
- PROTEIN_SECRETION+0.001
- MYC_TARGETS_V2-0.039
- PI3K_AKT_MTOR_SIGNALING-0.039
- UNFOLDED_PROTEIN_RESPONSE-0.046
- SPERMATOGENESIS-0.053
- MYC_TARGETS_V1-0.084
- HEME_METABOLISM-0.090
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.589
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.523
- INTERFERON_GAMMA_RESPONSE-0.518
- TNFA_SIGNALING_VIA_NFKB-0.507
- TGF_BETA_SIGNALING-0.500
- INFLAMMATORY_RESPONSE-0.490
- NOTCH_SIGNALING-0.479
- IL6_JAK_STAT3_SIGNALING-0.474
- ANGIOGENESIS-0.451
- APOPTOSIS-0.446
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1338323 | GTEX | — | 0.987 |
| 2 | SRR1429935 | GTEX | — | 0.987 |
| 3 | SRR1476632 | GTEX | — | 0.986 |
| 4 | SRR1317808 | GTEX | — | 0.985 |
| 5 | SRR1331841 | GTEX | — | 0.984 |
| 6 | SRR1340095 | GTEX | — | 0.984 |
| 7 | SRR1475737 | GTEX | — | 0.983 |
| 8 | SRR1490382 | GTEX | — | 0.982 |
| 9 | SRR1456841 | GTEX | — | 0.982 |
| 10 | SRR1434782 | GTEX | — | 0.982 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 4 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| DNA_REPAIR | 0.121 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.024 | Remibrutinib | — uncovered |
| MITOTIC_SPINDLE | 0.020 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.001 | Remibrutinib | — uncovered |