SRR1386708
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.491
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.323
- SPERMATOGENESIS+0.209
- KRAS_SIGNALING_DN+0.176
- MYC_TARGETS_V2+0.114
- DNA_REPAIR+0.113
- FATTY_ACID_METABOLISM+0.094
- PANCREAS_BETA_CELLS+0.083
- PEROXISOME+0.059
- PROTEIN_SECRETION+0.044
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.609
- INTERFERON_GAMMA_RESPONSE-0.532
- IL6_JAK_STAT3_SIGNALING-0.493
- TGF_BETA_SIGNALING-0.476
- ALLOGRAFT_REJECTION-0.454
- NOTCH_SIGNALING-0.426
- TNFA_SIGNALING_VIA_NFKB-0.426
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.417
- INFLAMMATORY_RESPONSE-0.415
- G2M_CHECKPOINT-0.378
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1362219 | GTEX | — | 0.976 |
| 2 | SRR1315970 | GTEX | — | 0.966 |
| 3 | SRR1408208 | GTEX | — | 0.962 |
| 4 | SRR662233 | GTEX | — | 0.960 |
| 5 | SRR1416477 | GTEX | — | 0.957 |
| 6 | SRR1360563 | GTEX | — | 0.956 |
| 7 | SRR1386818 | GTEX | — | 0.953 |
| 8 | SRR1453341 | GTEX | — | 0.951 |
| 9 | SRR1328895 | GTEX | — | 0.949 |
| 10 | SRR821626 | GTEX | — | 0.946 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 15 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.491 | Remibrutinib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.323 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.209 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.176 | Remibrutinib | — uncovered |
| MYC_TARGETS_V2 | 0.114 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.113 | Idelalisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.094 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.083 | Cobimetinib | — uncovered |
| PEROXISOME | 0.059 | Idelalisib | — uncovered |
| PROTEIN_SECRETION | 0.044 | Remibrutinib | — uncovered |
| HEME_METABOLISM | 0.041 | Temsirolimus | — uncovered |
| UV_RESPONSE_UP | 0.041 | Idelalisib | — uncovered |
| APICAL_SURFACE | 0.037 | Temsirolimus | — uncovered |
| ADIPOGENESIS | 0.029 | Inavolisib | — uncovered |
| GLYCOLYSIS | 0.014 | Inavolisib | — uncovered |