Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-GU-AATQ-01A-11R-A39I-07

e014bf15-a51d-5d5a-8228-9d4277b9eff6

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
6.997371879
os_event
true
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • MYC_TARGETS_V2+0.510
  • MYC_TARGETS_V1+0.490
  • G2M_CHECKPOINT+0.480
  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.480
  • E2F_TARGETS+0.470
  • MTORC1_SIGNALING+0.380
  • DNA_REPAIR+0.290
  • OXIDATIVE_PHOSPHORYLATION+0.280
  • PI3K_AKT_MTOR_SIGNALING+0.270
  • CHOLESTEROL_HOMEOSTASIS+0.240

Top 10 suppressed

  • TNFA_SIGNALING_VIA_NFKB-0.390
  • TGF_BETA_SIGNALING-0.280
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.270
  • HEDGEHOG_SIGNALING-0.240
  • APOPTOSIS-0.210
  • IL2_STAT5_SIGNALING-0.200
  • INFLAMMATORY_RESPONSE-0.200
  • KRAS_SIGNALING_UP-0.180
  • COMPLEMENT-0.170
  • ALLOGRAFT_REJECTION-0.140

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1C3N-03204
lung-landscapes@6
cohortSQ20.879
2MNG358
mng-umap@100
0.869
3SRR6013575
lung-landscapes@6
cohortSQ20.862
4TCGA-85-8277-01A-11R-2296-07
lung-landscapes@6
cohortSQ20.855
5fddf611e-f586-49e1-9ee8-8ac853accb9e
colon-landscapes@1
0.852
6TCGA-66-2727-01A-01R-0980-07
lung-landscapes@6
cohortSQ20.851
7TCGA-A8-A092-01A-11R-A00Z-07
breast-umap@18
B0.846
8TCGA-NC-A5HN-01A-11R-A26W-07
lung-landscapes@6
cohortSQ20.837
9SRR8518230
breast-umap@18
E0.836
10SRR8613729
breast-umap@18
E0.834

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 26 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V20.510Idelalisib— uncovered
MYC_TARGETS_V10.490Inavolisib— uncovered
G2M_CHECKPOINT0.480Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.480Inavolisib— uncovered
E2F_TARGETS0.470Inavolisib— uncovered
MTORC1_SIGNALING0.380Inavolisib— uncovered
DNA_REPAIR0.290Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.280Remibrutinib— uncovered
PI3K_AKT_MTOR_SIGNALING0.270Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.240Remibrutinib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.220Idelalisib— uncovered
GLYCOLYSIS0.210Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.180Inavolisib— uncovered
FATTY_ACID_METABOLISM0.150Inavolisib— uncovered
MITOTIC_SPINDLE0.140Inavolisib— uncovered
SPERMATOGENESIS0.120Inavolisib— uncovered
ADIPOGENESIS0.100Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.080Idelalisib— uncovered
UV_RESPONSE_UP0.070Idelalisib— uncovered
MYOGENESIS0.060Inavolisib— uncovered