Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-BH-A0GY-01A-11R-A056-07

· C

e1210273-0070-5889-9d6c-ed5df2308874

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
C
subtype
C
overall_survival_months
31

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
16e639239-cdae-4412-880f-ef813a956ff7
colon-landscapes@1
0.847
2DRR168585
bladder-landscape@3
0.823
3SRR6013500
lung-landscapes@6
cohortA10.812
4BS_850BAHH9
brain-umap@2
ATRT0.811
5DRR168606
bladder-landscape@3
0.804
6BS_996ZS2A4
brain-umap@2
ATRT0.804
7SRR6013499
lung-landscapes@6
cohortA10.804
84c8b5d7c-d82b-4504-9b9e-3946ca14251e
colon-landscapes@1
0.796
9SRR26320090
bladder-landscape@3
0.795
10SRR8613733
breast-umap@18
C0.794

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 40 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V20.410Idelalisib— uncovered
MYC_TARGETS_V10.350Inavolisib— uncovered
MTORC1_SIGNALING0.340Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.310Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.310Idelalisib— uncovered
COMPLEMENT0.280Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.280Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.260Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.260Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.250Inavolisib— uncovered
E2F_TARGETS0.240Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.240Inavolisib— uncovered
UV_RESPONSE_UP0.240Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.230Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.230Idelalisib— uncovered
ANGIOGENESIS0.210Remibrutinib— uncovered
ALLOGRAFT_REJECTION0.200Idelalisib— uncovered
IL2_STAT5_SIGNALING0.200Idelalisib— uncovered
PROTEIN_SECRETION0.180Remibrutinib— uncovered
APOPTOSIS0.170Idelalisib— uncovered