SRR5088913
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.300
- MYOGENESIS+0.300
- UV_RESPONSE_DN+0.200
- INTERFERON_GAMMA_RESPONSE+0.100
- KRAS_SIGNALING_DN+0.100
- SPERMATOGENESIS+0.100
- ALLOGRAFT_REJECTION+0.000
- ANDROGEN_RESPONSE+0.000
- HEDGEHOG_SIGNALING+0.000
- HEME_METABOLISM+0.000
Top 10 suppressed
- E2F_TARGETS-0.500
- G2M_CHECKPOINT-0.500
- ANGIOGENESIS-0.400
- CHOLESTEROL_HOMEOSTASIS-0.400
- DNA_REPAIR-0.400
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.400
- MTORC1_SIGNALING-0.400
- MYC_TARGETS_V2-0.400
- COAGULATION-0.300
- GLYCOLYSIS-0.300
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR11296732 | — | — | 0.845 |
| 2 | SAMN03290914 | — | — | 0.840 |
| 3 | SRR4195656 | — | — | 0.832 |
| 4 | C3N-03057 | — | cohortA1 | 0.825 |
| 5 | C3N-03054 | — | cohortA1 | 0.820 |
| 6 | MDT-AP-0810 | Med | Medulloblastoma | 0.820 |
| 7 | TCGA-NJ-A55A-01A-11R-A262-07 | — | cohortA1 | 0.818 |
| 8 | C3N-01799 | — | cohortA1 | 0.817 |
| 9 | SRR8943010 | — | — | 0.817 |
| 10 | SRR12696737 | — | — | 0.817 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.300 | Inavolisib | — uncovered |
| MYOGENESIS | 0.300 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.200 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.100 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.100 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.100 | Inavolisib | — uncovered |