SAMN03290914
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.400
- INTERFERON_GAMMA_RESPONSE+0.200
- ALLOGRAFT_REJECTION+0.100
- PANCREAS_BETA_CELLS+0.100
- ANDROGEN_RESPONSE+0.000
- HEDGEHOG_SIGNALING+0.000
- KRAS_SIGNALING_DN+0.000
- PROTEIN_SECRETION+0.000
- SPERMATOGENESIS+0.000
- BILE_ACID_METABOLISM-0.100
Top 10 suppressed
- ANGIOGENESIS-0.500
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.500
- ADIPOGENESIS-0.400
- APICAL_JUNCTION-0.400
- CHOLESTEROL_HOMEOSTASIS-0.400
- E2F_TARGETS-0.400
- ESTROGEN_RESPONSE_EARLY-0.400
- ESTROGEN_RESPONSE_LATE-0.400
- G2M_CHECKPOINT-0.400
- GLYCOLYSIS-0.400
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SAMN03290916 | — | — | 0.906 |
| 2 | SRR25617833 | — | B | 0.898 |
| 3 | SRR12202414 | — | — | 0.883 |
| 4 | SRR33346946 | — | — | 0.880 |
| 5 | SRR11296732 | — | — | 0.870 |
| 6 | AUR-AD9G-TTP1-B-4-0-R-A584-39 | — | D | 0.867 |
| 7 | MDT-AP-1327 | Med | Medulloblastoma | 0.866 |
| 8 | TCGA-MP-A4T6-01A-32R-A262-07 | — | cohortA1 | 0.864 |
| 9 | ERR2208899 | — | — | 0.859 |
| 10 | AUR-AF9A-TTP1-A-1-0-R-A741-41 | — | D | 0.858 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 4 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.400 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.200 | Idelalisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.100 | Idelalisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.100 | Cobimetinib | — uncovered |