ERR2598102
fetal · fetal
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- fetal
- cancer_type_detailed
- —
- subtype
- fetal
- cancer_type
- fetal
- subtype
- fetal
- sex
- fetal
- race
- fetal
- fetal_age_forebrain
- 13
- umap1_2d
- -4.108251615
- umap2_2d
- 1.656501306
- umap1_3d
- -1.978371933
- umap2_3d
- 1.949089045
- umap3_3d
- -2.617532101
- dataset
- fetal
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- G2M_CHECKPOINT+0.570
- E2F_TARGETS+0.560
- MYC_TARGETS_V1+0.550
- MITOTIC_SPINDLE+0.480
- DNA_REPAIR+0.420
- MYC_TARGETS_V2+0.390
- PROTEIN_SECRETION+0.370
- ANDROGEN_RESPONSE+0.280
- CHOLESTEROL_HOMEOSTASIS+0.270
- HEDGEHOG_SIGNALING+0.240
Top 10 suppressed
- INFLAMMATORY_RESPONSE-0.430
- IL6_JAK_STAT3_SIGNALING-0.420
- ALLOGRAFT_REJECTION-0.350
- INTERFERON_GAMMA_RESPONSE-0.350
- KRAS_SIGNALING_DN-0.350
- TNFA_SIGNALING_VIA_NFKB-0.350
- ANGIOGENESIS-0.330
- IL2_STAT5_SIGNALING-0.330
- INTERFERON_ALPHA_RESPONSE-0.310
- ESTROGEN_RESPONSE_LATE-0.300
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | E3A67B7B-7427-4C11-912B-166451072767 | — | — | 0.941 |
| 2 | 2DA298A9-AB20-4F9D-B83F-C7FC0679F889 | — | — | 0.922 |
| 3 | 332283CB-F855-4493-A259-7852FD37B9DC | — | — | 0.915 |
| 4 | 713B4DA5-FA8A-4E52-BACF-19B912467FBB | — | — | 0.911 |
| 5 | 2C70D7BF-85C4-447B-B0F9-A129D6B49E77 | — | — | 0.907 |
| 6 | 10FB7E59-9D71-4AB9-8D06-9CFD2304D1BC | — | — | 0.903 |
| 7 | 800E78BA-08BE-463B-ABBA-45255B48362B | — | — | 0.903 |
| 8 | 19EBA5E0-D299-4166-834A-256294572121 | — | — | 0.900 |
| 9 | ERR2598198 | fetal | fetal | 0.900 |
| 10 | CB9E4206-E2F7-49EA-8FB2-E69E5BB3B018 | — | — | 0.899 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 22 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| G2M_CHECKPOINT | 0.570 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.560 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.550 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.480 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.420 | Idelalisib | — uncovered |
| MYC_TARGETS_V2 | 0.390 | Idelalisib | — uncovered |
| PROTEIN_SECRETION | 0.370 | Remibrutinib | — uncovered |
| ANDROGEN_RESPONSE | 0.280 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.270 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.240 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.230 | Idelalisib | — uncovered |
| NOTCH_SIGNALING | 0.200 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.170 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.160 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.130 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.120 | Remibrutinib | — uncovered |
| PEROXISOME | 0.120 | Idelalisib | — uncovered |
| ADIPOGENESIS | 0.090 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.080 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.080 | Temsirolimus | — uncovered |