Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

MNG97

e49182dc-4659-5822-bc8a-7959af26a913

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR6013555
lung-landscapes@6
cohortMD20.798
2SRR27320680
colon-landscapes@1
0.791
3MNG628
mng-umap@100
0.771
4SRR4296112
lung-landscapes@6
cohortA10.763
5TCGA-86-7954-01A-11R-2187-07
lung-landscapes@6
cohortA10.762
6GSM6454734
breast-umap@18
D0.747
7MNG1048
mng-umap@100
0.746
8SRR33532827
breast-umap@18
D0.743
9TCGA-80-5611-01A-01R-1628-07
lung-landscapes@6
cohortA40.731
10aMVAC.P_006_TURBT_S224
bladder-landscape@3
0.726

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 27 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.587Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.477Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.430Remibrutinib— uncovered
ALLOGRAFT_REJECTION0.428Idelalisib— uncovered
PROTEIN_SECRETION0.399Remibrutinib— uncovered
COMPLEMENT0.297Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.266Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.231Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.221Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.209Inavolisib— uncovered
ADIPOGENESIS0.206Inavolisib— uncovered
NOTCH_SIGNALING0.203Inavolisib— uncovered
MYC_TARGETS_V10.199Inavolisib— uncovered
FATTY_ACID_METABOLISM0.179Inavolisib— uncovered
MITOTIC_SPINDLE0.136Inavolisib— uncovered
HEME_METABOLISM0.062Temsirolimus— uncovered
MTORC1_SIGNALING0.052Inavolisib— uncovered
IL2_STAT5_SIGNALING0.049Idelalisib— uncovered
BILE_ACID_METABOLISM0.042Inavolisib— uncovered
APICAL_SURFACE0.041Temsirolimus— uncovered