Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-B6-A0I6-01A-11R-A034-07

· E

e494cca8-6ae5-5b24-ba82-0538844648ed

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
E
subtype
E
overall_survival_months
33

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-AN-A0FX-01A-11R-A034-07
breast-umap@18
E0.921
2C3N-03662
lung-landscapes@6
cohortSQ20.892
3TCGA-AR-A0TP-01A-11R-A084-07
breast-umap@18
E0.890
4SRR8518399
breast-umap@18
E0.864
520130126.TNBC
breast-umap@18
E0.853
6SRR8613771
breast-umap@18
E0.847
7C3L-00445
lung-landscapes@6
cohortSQ20.846
8TCGA-AR-A2LR-01A-12R-A18M-07
breast-umap@18
E0.843
920110025.TNBC
breast-umap@18
E0.839
10TCGA-AN-A0FJ-01A-11R-A00Z-07
breast-umap@18
E0.838

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 27 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
E2F_TARGETS0.560Inavolisib— uncovered
G2M_CHECKPOINT0.520Inavolisib— uncovered
MITOTIC_SPINDLE0.400Inavolisib— uncovered
HEDGEHOG_SIGNALING0.390Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.350Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.340Inavolisib— uncovered
MYC_TARGETS_V20.280Idelalisib— uncovered
HYPOXIA0.250Idelalisib— uncovered
MYC_TARGETS_V10.240Inavolisib— uncovered
SPERMATOGENESIS0.190Inavolisib— uncovered
APICAL_JUNCTION0.180Inavolisib— uncovered
MYOGENESIS0.180Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.150Remibrutinib— uncovered
NOTCH_SIGNALING0.150Inavolisib— uncovered
ANGIOGENESIS0.140Remibrutinib— uncovered
UV_RESPONSE_UP0.130Idelalisib— uncovered
MTORC1_SIGNALING0.120Inavolisib— uncovered
GLYCOLYSIS0.110Inavolisib— uncovered
KRAS_SIGNALING_DN0.110Remibrutinib— uncovered
TGF_BETA_SIGNALING0.090Inavolisib— uncovered