SRR1311400
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.338
- SPERMATOGENESIS+0.294
- OXIDATIVE_PHOSPHORYLATION+0.186
- HEDGEHOG_SIGNALING+0.184
- PANCREAS_BETA_CELLS+0.167
- APICAL_JUNCTION+0.125
- UV_RESPONSE_UP+0.084
- MYOGENESIS+0.082
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.049
- APICAL_SURFACE+0.001
Top 10 suppressed
- IL6_JAK_STAT3_SIGNALING-0.528
- INTERFERON_ALPHA_RESPONSE-0.463
- INTERFERON_GAMMA_RESPONSE-0.461
- E2F_TARGETS-0.419
- TGF_BETA_SIGNALING-0.417
- G2M_CHECKPOINT-0.411
- MYC_TARGETS_V1-0.408
- PROTEIN_SECRETION-0.401
- ALLOGRAFT_REJECTION-0.369
- ANDROGEN_RESPONSE-0.367
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1357523 | GTEX | — | 0.976 |
| 2 | SRR660933 | GTEX | — | 0.966 |
| 3 | SRR1417047 | GTEX | — | 0.963 |
| 4 | SRR1399028 | GTEX | — | 0.962 |
| 5 | SRR1490019 | GTEX | — | 0.960 |
| 6 | SRR1335400 | GTEX | — | 0.959 |
| 7 | SRR1343841 | GTEX | — | 0.957 |
| 8 | SRR1459441 | GTEX | — | 0.956 |
| 9 | SRR1320093 | GTEX | — | 0.955 |
| 10 | SRR1323746 | GTEX | — | 0.954 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.338 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.294 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.186 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.184 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.167 | Cobimetinib | — uncovered |
| APICAL_JUNCTION | 0.125 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.084 | Idelalisib | — uncovered |
| MYOGENESIS | 0.082 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.049 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.001 | Temsirolimus | — uncovered |