Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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20090334.LumB

· B

e5fedc57-3dc2-5a95-988f-d1a92bd0598f

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
B
subtype
B

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

6 twins match this tumor's tissue · 4 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG250
mng-umap@100
0.844
220140057.LumB
breast-umap@18
B0.842
3MDT-AP-0349
medullo-epn-umap@date-based
MedMedulloblastoma0.841
4SRR1437306
brain-umap@2
GTEX0.835
520070161.TNBC
breast-umap@18
F0.834
6TCGA-AC-A3YJ-01A-11R-A22U-07
breast-umap@18
B0.831
7TCGA-LL-A6FP-01A-11R-A31O-07
breast-umap@18
B0.831
8SRR1415095
brain-umap@2
GTEX0.822
9SRR1354689
brain-umap@2
GTEX0.822
1020140146.LumB
breast-umap@18
B0.821

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 13 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
OXIDATIVE_PHOSPHORYLATION0.370Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.360Cobimetinib— uncovered
ESTROGEN_RESPONSE_EARLY0.220Inavolisib— uncovered
FATTY_ACID_METABOLISM0.220Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.190Idelalisib— uncovered
BILE_ACID_METABOLISM0.120Inavolisib— uncovered
MYC_TARGETS_V10.120Inavolisib— uncovered
COAGULATION0.100Binimetinib— uncovered
DNA_REPAIR0.070Idelalisib— uncovered
KRAS_SIGNALING_DN0.070Remibrutinib— uncovered
ADIPOGENESIS0.060Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.030Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.020Inavolisib— uncovered