ERR2598318
fetal · fetal
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- fetal
- cancer_type_detailed
- —
- subtype
- fetal
- cancer_type
- fetal
- subtype
- fetal
- sex
- fetal
- race
- fetal
- fetal_age_hindbrain
- 20
- umap1_2d
- -4.947904571
- umap2_2d
- -1.893633957
- umap1_3d
- 0.504780834
- umap2_3d
- 2.438971321
- umap3_3d
- -0.686060412
- dataset
- fetal
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.570
- INTERFERON_GAMMA_RESPONSE+0.480
- COAGULATION+0.470
- IL6_JAK_STAT3_SIGNALING+0.470
- ALLOGRAFT_REJECTION+0.430
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.430
- COMPLEMENT+0.410
- INFLAMMATORY_RESPONSE+0.400
- KRAS_SIGNALING_UP+0.370
- TNFA_SIGNALING_VIA_NFKB+0.330
Top 10 suppressed
- MYC_TARGETS_V2-0.630
- MYC_TARGETS_V1-0.450
- E2F_TARGETS-0.360
- G2M_CHECKPOINT-0.350
- MTORC1_SIGNALING-0.340
- WNT_BETA_CATENIN_SIGNALING-0.310
- DNA_REPAIR-0.280
- UNFOLDED_PROTEIN_RESPONSE-0.280
- NOTCH_SIGNALING-0.270
- MITOTIC_SPINDLE-0.230
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | ERR2598319 | fetal | fetal | 0.929 |
| 2 | SRR1797302 | — | cohortMD2 | 0.897 |
| 3 | TCGA-38-4626-01A-01R-1206-07 | — | cohortMD2 | 0.896 |
| 4 | SRR5088905 | — | — | 0.896 |
| 5 | MDT-AP-2936 | Med | Medulloblastoma | 0.889 |
| 6 | sclc0617_S65.txt | — | cohortMD2 | 0.889 |
| 7 | ERR2598341 | fetal | fetal | 0.887 |
| 8 | SRR1435753 | GTEX | — | 0.885 |
| 9 | SRR600385 | GTEX | — | 0.884 |
| 10 | SRR975591 | — | — | 0.884 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 31 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.570 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.480 | Idelalisib | — uncovered |
| COAGULATION | 0.470 | Binimetinib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.470 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.430 | Idelalisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.430 | Inavolisib | — uncovered |
| COMPLEMENT | 0.410 | Inavolisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.400 | Idelalisib | — uncovered |
| KRAS_SIGNALING_UP | 0.370 | Inavolisib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.330 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.320 | Remibrutinib | — uncovered |
| IL2_STAT5_SIGNALING | 0.320 | Idelalisib | — uncovered |
| MYOGENESIS | 0.320 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.320 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.310 | Cobimetinib | — uncovered |
| HYPOXIA | 0.300 | Idelalisib | — uncovered |
| APOPTOSIS | 0.290 | Idelalisib | — uncovered |
| BILE_ACID_METABOLISM | 0.290 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.260 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.240 | Idelalisib | — uncovered |