MNG938
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.397
- UV_RESPONSE_DN+0.218
- WNT_BETA_CATENIN_SIGNALING+0.197
- MITOTIC_SPINDLE+0.181
- DNA_REPAIR+0.168
- MYC_TARGETS_V2+0.077
- APICAL_JUNCTION+0.033
- PEROXISOME+0.022
- UNFOLDED_PROTEIN_RESPONSE+0.021
- INTERFERON_GAMMA_RESPONSE+0.002
Top 10 suppressed
- TNFA_SIGNALING_VIA_NFKB-0.493
- MTORC1_SIGNALING-0.452
- ANGIOGENESIS-0.442
- PANCREAS_BETA_CELLS-0.419
- INFLAMMATORY_RESPONSE-0.414
- CHOLESTEROL_HOMEOSTASIS-0.403
- ALLOGRAFT_REJECTION-0.385
- APICAL_SURFACE-0.376
- COMPLEMENT-0.337
- ESTROGEN_RESPONSE_LATE-0.336
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG230 | — | — | 0.842 |
| 2 | MNG909 | — | — | 0.818 |
| 3 | MDT-AP-0329 | Med | Medulloblastoma | 0.807 |
| 4 | MNG881 | — | — | 0.803 |
| 5 | MBCproject_6016_T1_RNA | — | A | 0.793 |
| 6 | SRR4296062 | — | cohortA1 | 0.792 |
| 7 | MNG54 | — | — | 0.792 |
| 8 | aMVAC.P_002_TURBT_S219 | — | — | 0.776 |
| 9 | SRR5088920 | — | — | 0.768 |
| 10 | SRR650134 | — | — | 0.767 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.397 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.218 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.197 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.181 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.168 | Idelalisib | — uncovered |
| MYC_TARGETS_V2 | 0.077 | Idelalisib | — uncovered |
| APICAL_JUNCTION | 0.033 | Inavolisib | — uncovered |
| PEROXISOME | 0.022 | Idelalisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.021 | Idelalisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.002 | Idelalisib | — uncovered |