SRR4296062
— · cohortA1
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortA1
- subtype
- cohortA1
- age_years
- 57
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- DNA_REPAIR+0.230
- MYOGENESIS+0.130
- TGF_BETA_SIGNALING+0.120
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.090
- APICAL_JUNCTION+0.080
- HEDGEHOG_SIGNALING+0.050
- OXIDATIVE_PHOSPHORYLATION+0.020
- WNT_BETA_CATENIN_SIGNALING+0.000
- NOTCH_SIGNALING-0.030
- SPERMATOGENESIS-0.050
Top 10 suppressed
- MTORC1_SIGNALING-0.450
- INFLAMMATORY_RESPONSE-0.430
- TNFA_SIGNALING_VIA_NFKB-0.430
- G2M_CHECKPOINT-0.410
- IL6_JAK_STAT3_SIGNALING-0.410
- CHOLESTEROL_HOMEOSTASIS-0.390
- HYPOXIA-0.380
- FATTY_ACID_METABOLISM-0.360
- UNFOLDED_PROTEIN_RESPONSE-0.360
- PANCREAS_BETA_CELLS-0.350
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1516075 | — | — | 0.855 |
| 2 | ea635e80-1225-4f52-a6cf-8f4c20201240 | — | — | 0.844 |
| 3 | 9ff8aa32-18fe-439b-a83c-e39282bd3421 | — | — | 0.840 |
| 4 | AUR-AFE5-TTM9-A-1-1-R-A742-41 | — | D | 0.839 |
| 5 | TCGA-FD-A43X-01A-11R-A23W-07 | — | — | 0.835 |
| 6 | EPT0291 | EPN | EPN Tumor | 0.826 |
| 7 | SRR650134 | — | — | 0.825 |
| 8 | MBCProject_0719_T1_RNA | — | A | 0.820 |
| 9 | TCGA-90-A4ED-01A-31R-A24Z-07 | — | cohortMD1 | 0.819 |
| 10 | SRR25617883 | — | B | 0.818 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| DNA_REPAIR | 0.230 | Idelalisib | — uncovered |
| MYOGENESIS | 0.130 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.120 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.090 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.080 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.050 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.020 | Remibrutinib | — uncovered |