ERR2598072
fetal · fetal
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- fetal
- cancer_type_detailed
- —
- subtype
- fetal
- cancer_type
- fetal
- subtype
- fetal
- sex
- fetal
- race
- fetal
- fetal_age_forebrain
- 11
- umap1_2d
- -4.479847076
- umap2_2d
- 1.599915769
- umap1_3d
- -2.111703489
- umap2_3d
- 2.149110736
- umap3_3d
- -2.467669472
- dataset
- fetal
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYC_TARGETS_V2+0.520
- G2M_CHECKPOINT+0.500
- E2F_TARGETS+0.490
- DNA_REPAIR+0.400
- MITOTIC_SPINDLE+0.370
- CHOLESTEROL_HOMEOSTASIS+0.350
- MYC_TARGETS_V1+0.340
- HEDGEHOG_SIGNALING+0.300
- WNT_BETA_CATENIN_SIGNALING+0.290
- UNFOLDED_PROTEIN_RESPONSE+0.250
Top 10 suppressed
- PROTEIN_SECRETION-0.360
- INFLAMMATORY_RESPONSE-0.330
- IL6_JAK_STAT3_SIGNALING-0.290
- INTERFERON_GAMMA_RESPONSE-0.280
- INTERFERON_ALPHA_RESPONSE-0.260
- ALLOGRAFT_REJECTION-0.230
- PANCREAS_BETA_CELLS-0.220
- BILE_ACID_METABOLISM-0.150
- SPERMATOGENESIS-0.150
- ANGIOGENESIS-0.130
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | ERR2598071 | fetal | fetal | 0.892 |
| 2 | ERR2598252 | fetal | fetal | 0.848 |
| 3 | TCGA-77-8153-01A-11R-2403-07 | — | cohortSQ2 | 0.823 |
| 4 | MDT-AP-0513 | Med | Medulloblastoma | 0.822 |
| 5 | TCGA-85-A4CN-01A-11R-A24H-07 | — | cohortSQ2 | 0.819 |
| 6 | EB098C15-F710-411C-A981-D750310554F8 | — | — | 0.804 |
| 7 | ERR2598070 | fetal | fetal | 0.803 |
| 8 | BS_S0175QKX | EPN | Posterior Fossa EPN | 0.797 |
| 9 | 8EFF99B7-0009-4638-8212-0D3EAF1AC2A5 | — | — | 0.795 |
| 10 | TCGA-85-8052-01A-11R-2247-07 | — | cohortSQ2 | 0.794 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 25 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V2 | 0.520 | Idelalisib | — uncovered |
| G2M_CHECKPOINT | 0.500 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.490 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.400 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.370 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.350 | Remibrutinib | — uncovered |
| MYC_TARGETS_V1 | 0.340 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.300 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.290 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.250 | Idelalisib | — uncovered |
| TGF_BETA_SIGNALING | 0.180 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.120 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.120 | Temsirolimus | — uncovered |
| HEME_METABOLISM | 0.110 | Temsirolimus | — uncovered |
| NOTCH_SIGNALING | 0.110 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.110 | Idelalisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.080 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.070 | Inavolisib | — uncovered |
| COAGULATION | 0.070 | Binimetinib | — uncovered |
| PEROXISOME | 0.070 | Idelalisib | — uncovered |