Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · head-neck@1

TCGA-IQ-A61J-01A-11R-A30B-07

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e8ef2eb4-c1b3-52b0-aa52-bfc5b5bd6773

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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sex
male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR15069598
head-neck@1
——0.909
26b32f047-89ca-40e7-950f-a03493ea90c7
colon-landscapes@1
——0.896
3TCGA-CV-5444-01A-02R-1514-07
head-neck@1
——0.888
4TCGA-49-AARR-01A-11R-A41B-07
lung-landscapes@6
—cohortA10.887
5TCGA-75-7025-01A-12R-1949-07
lung-landscapes@6
—cohortA10.886
6C3L-03268
lung-landscapes@6
—cohortA10.885
744eb0b78-9761-4131-b831-85e765a24e6b
colon-landscapes@1
——0.885
8TCGA-L9-A443-01A-12R-A24H-07
lung-landscapes@6
—cohortA10.883
9TCGA-44-6147-01A-11R-1755-07
lung-landscapes@6
—cohortA10.881
10TCGA-G2-A2EC-01A-11R-A180-07
bladder-landscape@3
——0.875

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 19 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYOGENESIS0.550Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.370Inavolisib— uncovered
KRAS_SIGNALING_DN0.270Remibrutinib— uncovered
ANGIOGENESIS0.260Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.240Cobimetinib— uncovered
KRAS_SIGNALING_UP0.210Inavolisib— uncovered
BILE_ACID_METABOLISM0.180Inavolisib— uncovered
UV_RESPONSE_DN0.180Inavolisib— uncovered
COAGULATION0.170Binimetinib— uncovered
TGF_BETA_SIGNALING0.160Inavolisib— uncovered
APICAL_JUNCTION0.150Inavolisib— uncovered
APICAL_SURFACE0.150Temsirolimus— uncovered
NOTCH_SIGNALING0.150Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.110Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.090Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.070Inavolisib— uncovered
P53_PATHWAY0.050Idelalisib— uncovered
HEME_METABOLISM0.030Temsirolimus— uncovered
IL2_STAT5_SIGNALING0.030Idelalisib— uncovered