TCGA-95-A4VK-01A-11R-A262-07

— · cohortA4

eb048bde-0375-5b86-8e30-296e66c3f2cd

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: cohortA4
subtype: cohortA4
age_years: 74

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	TCGA-55-A4DG-01A-11R-A24H-07 lung-landscapes@6	—	cohortA1	0.885
2	TCGA-69-7764-01A-11R-2170-07 lung-landscapes@6	—	cohortA2	0.875
3	TCGA-97-A4M1-01A-11R-A24X-07 lung-landscapes@6	—	cohortA1	0.859
4	BS_C80S5N37 brain-umap@2	Ependymoma NOS	—	0.855
5	SRR8526730 lung-landscapes@6	—	cohortA1	0.853
6	BS_C80S5N37 medullo-epn-umap@date-based	EPN	EPN Tumor	0.847
7	C3N-03212 lung-landscapes@6	—	cohortA1	0.845
8	C3L-02958 lung-landscapes@6	—	cohortA1	0.837
9	TCGA-NJ-A7XG-01A-12R-A39D-07 lung-landscapes@6	—	cohortA1	0.836
10	C3N-00293 lung-landscapes@6	—	cohortA1	0.835

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 12 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
WNT_BETA_CATENIN_SIGNALING	0.210	Inavolisib	— uncovered
NOTCH_SIGNALING	0.200	Inavolisib	— uncovered
CHOLESTEROL_HOMEOSTASIS	0.170	Remibrutinib	— uncovered
KRAS_SIGNALING_DN	0.110	Remibrutinib	— uncovered
INTERFERON_ALPHA_RESPONSE	0.080	Inavolisib	— uncovered
XENOBIOTIC_METABOLISM	0.080	Inavolisib	— uncovered
COAGULATION	0.070	Binimetinib	— uncovered
ESTROGEN_RESPONSE_EARLY	0.050	Inavolisib	— uncovered
MYOGENESIS	0.050	Inavolisib	— uncovered
BILE_ACID_METABOLISM	0.040	Inavolisib	— uncovered
FATTY_ACID_METABOLISM	0.020	Inavolisib	— uncovered
UV_RESPONSE_DN	0.020	Inavolisib	— uncovered