SRR8526730

— · cohortA1

701dc062-b666-58c5-a7ae-7b3994cc0050

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: cohortA1
subtype: cohortA1

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

HEDGEHOG_SIGNALING+0.260
UV_RESPONSE_DN+0.220
BILE_ACID_METABOLISM+0.210
WNT_BETA_CATENIN_SIGNALING+0.160
NOTCH_SIGNALING+0.120
INTERFERON_ALPHA_RESPONSE+0.010
PEROXISOME+0.000
APICAL_JUNCTION-0.020
KRAS_SIGNALING_DN-0.020
APICAL_SURFACE-0.040

Top 10 suppressed

MYC_TARGETS_V1-0.650
E2F_TARGETS-0.590
MTORC1_SIGNALING-0.560
G2M_CHECKPOINT-0.550
OXIDATIVE_PHOSPHORYLATION-0.530
MYC_TARGETS_V2-0.520
UNFOLDED_PROTEIN_RESPONSE-0.420
PROTEIN_SECRETION-0.410
ANGIOGENESIS-0.380
REACTIVE_OXYGEN_SPECIES_PATHWAY-0.370

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	C3N-00293 lung-landscapes@6	—	cohortA1	0.915
2	TCGA-NJ-A55A-01A-11R-A262-07 lung-landscapes@6	—	cohortA1	0.909
3	SRR1313120 breast-umap@18	—	A	0.901
4	TCGA-55-A4DG-01A-11R-A24H-07 lung-landscapes@6	—	cohortA1	0.899
5	b03ebc32.a177.44c7.8b02.fcd6560712f2 lung-landscapes@6	—	cohortA1	0.894
6	TCGA-A7-A13G-01B-04R-A22O-07 breast-umap@18	—	D	0.884
7	SRR2016932 head-neck@1	—	—	0.881
8	C3L-04759 lung-landscapes@6	—	cohortA1	0.877
9	BS_4W68NV3M medullo-epn-umap@date-based	Med	Medulloblastoma	0.875
10	SRR6013544 lung-landscapes@6	—	cohortA1	0.875

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 6 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
HEDGEHOG_SIGNALING	0.260	Inavolisib	— uncovered
UV_RESPONSE_DN	0.220	Inavolisib	— uncovered
BILE_ACID_METABOLISM	0.210	Inavolisib	— uncovered
WNT_BETA_CATENIN_SIGNALING	0.160	Inavolisib	— uncovered
NOTCH_SIGNALING	0.120	Inavolisib	— uncovered
INTERFERON_ALPHA_RESPONSE	0.010	Inavolisib	— uncovered