Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
KIRhub 2.0
Sign in

f5760366-59eb-417d-a935-3f78e999dd42

ec48dc5a-65f2-5573-b2d0-672b0c16e8de

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.700
  • ALLOGRAFT_REJECTION+0.600
  • INTERFERON_GAMMA_RESPONSE+0.600
  • IL6_JAK_STAT3_SIGNALING+0.500
  • INFLAMMATORY_RESPONSE+0.400
  • COMPLEMENT+0.300
  • PANCREAS_BETA_CELLS+0.300
  • COAGULATION+0.200
  • IL2_STAT5_SIGNALING+0.200
  • KRAS_SIGNALING_UP+0.200

Top 10 suppressed

  • MYC_TARGETS_V2-0.400
  • NOTCH_SIGNALING-0.400
  • TGF_BETA_SIGNALING-0.400
  • E2F_TARGETS-0.300
  • MITOTIC_SPINDLE-0.300
  • MYC_TARGETS_V1-0.300
  • PROTEIN_SECRETION-0.300
  • UV_RESPONSE_DN-0.300
  • ADIPOGENESIS-0.200
  • ANDROGEN_RESPONSE-0.200

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SAMN03290925
melanoma-umap@29
0.894
2R13
bladder-landscape@3
0.865
394b2af92-0cfc-40b2-977d-6bd0fa4440d9
melanoma-umap@29
0.865
4SRR25617853
breast-umap@18
D0.860
5SRR8518255
breast-umap@18
D0.855
6TCGA-55-6987-01A-11R-1949-07
lung-landscapes@6
cohortMD20.852
75566453e-df41-4aab-8dd0-825efbece954
melanoma-umap@29
0.843
8aeac6db7-09bd-45f9-a5fd-c8358f86bff8
melanoma-umap@29
0.841
9TCGA-AC-A5XS-01A-11R-A29R-07
breast-umap@18
B0.839
10ff12dc45-d7ab-45ae-a049-2d20e3c546b6
melanoma-umap@29
0.839