aMVAC.P_001_TURBT_S217
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.350
- ADIPOGENESIS+0.220
- PEROXISOME+0.200
- BILE_ACID_METABOLISM+0.190
- CHOLESTEROL_HOMEOSTASIS+0.140
- UNFOLDED_PROTEIN_RESPONSE+0.140
- ANDROGEN_RESPONSE+0.100
- ESTROGEN_RESPONSE_EARLY+0.090
- PI3K_AKT_MTOR_SIGNALING+0.070
- FATTY_ACID_METABOLISM+0.050
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.570
- INTERFERON_ALPHA_RESPONSE-0.560
- ALLOGRAFT_REJECTION-0.550
- ANGIOGENESIS-0.550
- TNFA_SIGNALING_VIA_NFKB-0.520
- INFLAMMATORY_RESPONSE-0.490
- INTERFERON_GAMMA_RESPONSE-0.490
- IL6_JAK_STAT3_SIGNALING-0.480
- E2F_TARGETS-0.440
- KRAS_SIGNALING_UP-0.440
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-MP-A5C7-01A-11R-A262-07 | — | cohortA2 | 0.903 |
| 2 | DRR168589 | — | — | 0.900 |
| 3 | TCGA-D8-A1JN-01A-11R-A13Q-07 | — | C | 0.878 |
| 4 | SRR8943016 | — | — | 0.876 |
| 5 | MDT-AP-3207 | Med | Medulloblastoma | 0.875 |
| 6 | TCGA-D8-A1XC-01A-11R-A14D-07 | — | B | 0.870 |
| 7 | SRR35579848 | — | B | 0.869 |
| 8 | C3L-03721 | — | cohortA2 | 0.868 |
| 9 | MBCProject_0343_T1_RNA | — | B | 0.862 |
| 10 | SRR8613720 | — | C | 0.861 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.350 | Remibrutinib | — uncovered |
| ADIPOGENESIS | 0.220 | Inavolisib | — uncovered |
| PEROXISOME | 0.200 | Idelalisib | — uncovered |
| BILE_ACID_METABOLISM | 0.190 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.140 | Remibrutinib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.140 | Idelalisib | — uncovered |
| ANDROGEN_RESPONSE | 0.100 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.090 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.070 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.050 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.040 | Temsirolimus | — uncovered |