SAMN03290915
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- ESTROGEN_RESPONSE_EARLY+0.400
- ESTROGEN_RESPONSE_LATE+0.400
- WNT_BETA_CATENIN_SIGNALING+0.400
- APICAL_JUNCTION+0.300
- APICAL_SURFACE+0.300
- CHOLESTEROL_HOMEOSTASIS+0.300
- COAGULATION+0.300
- HYPOXIA+0.300
- KRAS_SIGNALING_DN+0.300
- MYC_TARGETS_V2+0.300
Top 10 suppressed
- PROTEIN_SECRETION-0.500
- E2F_TARGETS-0.400
- G2M_CHECKPOINT-0.400
- MYC_TARGETS_V1-0.300
- ALLOGRAFT_REJECTION-0.200
- ANDROGEN_RESPONSE-0.200
- MITOTIC_SPINDLE-0.200
- MTORC1_SIGNALING-0.200
- UNFOLDED_PROTEIN_RESPONSE-0.200
- UV_RESPONSE_DN-0.200
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | 80bea63b-bc3a-4999-8c11-a35c92183cd7 | — | — | 0.868 |
| 2 | a4322796-9189-48c2-9e7c-7b1493b5799a | — | — | 0.839 |
| 3 | SAMN03290907 | — | — | 0.829 |
| 4 | 05167d53-0b47-4131-bfa4-450b236b9fd5 | — | — | 0.824 |
| 5 | 1e82995c-f318-4225-96d4-f1e98bcbf60b | — | — | 0.818 |
| 6 | 1c3d6580-0dc8-4346-a4f7-0bb404d4a245 | — | — | 0.814 |
| 7 | c0054cf0-8f4b-47b6-a8fc-63a1fd36bcc7 | — | — | 0.811 |
| 8 | SAMN03290888 | — | — | 0.810 |
| 9 | a8235ad1-0c5f-4a0b-b595-85ef3a1e49ff | — | — | 0.809 |
| 10 | 8f45c6c4-b98d-4e0b-9bb0-b5be3894076d | — | — | 0.805 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 26 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| ESTROGEN_RESPONSE_EARLY | 0.400 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.400 | Idelalisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.400 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.300 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.300 | Temsirolimus | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.300 | Remibrutinib | — uncovered |
| COAGULATION | 0.300 | Binimetinib | — uncovered |
| HYPOXIA | 0.300 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.300 | Remibrutinib | — uncovered |
| MYC_TARGETS_V2 | 0.300 | Idelalisib | — uncovered |
| P53_PATHWAY | 0.300 | Idelalisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.300 | Inavolisib | — uncovered |
| MYOGENESIS | 0.200 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.200 | Inavolisib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.200 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.200 | Idelalisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.200 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.100 | Inavolisib | — uncovered |
| COMPLEMENT | 0.100 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.100 | Inavolisib | — uncovered |