SRR8518289
— · E
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- E
- subtype
- E
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR8518323 | — | E | 0.920 |
| 2 | TCGA-C8-A1HM-01A-12R-A137-07 | — | C | 0.914 |
| 3 | TCGA-18-3416-01A-01R-0980-07 | — | cohortSQ2 | 0.914 |
| 4 | 58c2404d-b213-4a7f-a8fc-11081a88091b | — | — | 0.911 |
| 5 | TCGA-AR-A0TU-01A-31R-A109-07 | — | E | 0.906 |
| 6 | 20020093.Her2HRneg | — | E | 0.891 |
| 7 | TCGA-AR-A0TV-01A-21R-A084-07 | — | B | 0.890 |
| 8 | TCGA-E2-A14N-01A-31R-A137-07 | — | E | 0.877 |
| 9 | TCGA-AN-A0AJ-01A-11R-A00Z-07 | — | C | 0.875 |
| 10 | MNG277 | — | — | 0.874 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 24 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| E2F_TARGETS | 0.640 | Inavolisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.610 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.610 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.610 | Idelalisib | — uncovered |
| G2M_CHECKPOINT | 0.570 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.530 | Idelalisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.400 | Idelalisib | — uncovered |
| MTORC1_SIGNALING | 0.380 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.330 | Remibrutinib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.310 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.270 | Idelalisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.240 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.230 | Idelalisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.140 | Idelalisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.130 | Inavolisib | — uncovered |
| GLYCOLYSIS | 0.120 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.110 | Inavolisib | — uncovered |
| PEROXISOME | 0.100 | Idelalisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.090 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.080 | Inavolisib | — uncovered |