Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · lung-landscapes@6

C3L-02168

— · cohortSQ2

f1a516ff-787f-5305-a8dd-85f4e6507973

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
—
cancer_type_detailed
—
subtype
cohortSQ2
subtype
cohortSQ2
age_years
66.52429843

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-85-6798-01A-11R-1949-07
lung-landscapes@6
—cohortSQ20.887
2TCGA-34-5236-01A-21R-1820-07
lung-landscapes@6
—cohortSQ10.870
3C3N-03662
lung-landscapes@6
—cohortSQ20.867
4TCGA-85-A4CN-01A-11R-A24H-07
lung-landscapes@6
—cohortSQ20.859
5TCGA-22-5482-01A-01R-1635-07
lung-landscapes@6
—cohortSQ20.840
6MNG1297
mng-umap@100
——0.840
7TCGA-43-6770-01A-11R-1820-07
lung-landscapes@6
—cohortSQ20.838
8SRR35579803
breast-umap@18
—E0.820
9TCGA-92-7341-01A-31R-2045-07
lung-landscapes@6
—cohortSQ20.820
10TCGA-60-2708-01A-01R-0851-07
lung-landscapes@6
—cohortSQ10.816

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 33 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.530Inavolisib— uncovered
HEDGEHOG_SIGNALING0.530Inavolisib— uncovered
E2F_TARGETS0.410Inavolisib— uncovered
G2M_CHECKPOINT0.380Inavolisib— uncovered
MYC_TARGETS_V20.330Idelalisib— uncovered
MTORC1_SIGNALING0.310Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.300Remibrutinib— uncovered
MYC_TARGETS_V10.280Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.260Inavolisib— uncovered
HYPOXIA0.240Idelalisib— uncovered
APICAL_JUNCTION0.220Inavolisib— uncovered
APICAL_SURFACE0.200Temsirolimus— uncovered
MYOGENESIS0.190Inavolisib— uncovered
UV_RESPONSE_DN0.170Inavolisib— uncovered
PANCREAS_BETA_CELLS0.160Cobimetinib— uncovered
TGF_BETA_SIGNALING0.160Inavolisib— uncovered
ANGIOGENESIS0.140Remibrutinib— uncovered
MITOTIC_SPINDLE0.140Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.120Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.120Inavolisib— uncovered